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9/17/2026 5:48:21 AM | Browse: 0 | Download: 0
Publication Name World Journal of Hepatology
Manuscript ID 122845
Country Türkiye
Received
2026-04-29 03:32
Peer-Review Started
2026-04-29 03:33
First Decision by Editorial Office Director
Return for Revision
2026-06-24 06:29
Revised
2026-07-03 11:33
Publication Fee Transferred
Second Decision by Editor
2026-08-27 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-08-28 09:20
Articles in Press
2026-08-28 09:20
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-09-07 03:04
Publish the Manuscript Online
2026-09-17 05:48
ISSN 1948-5182 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Anesthesiology
Manuscript Type Basic Study
Article Title Effects of fullerenol C60 on hepatic ischemia-reperfusion injury in desflurane-anesthetized rats
Manuscript Source Invited Manuscript
All Author List Esat Kasapbasi, Cagri Ozdemir, Aydin Yavuz, Saban Cem Sezen, Omer Kurtipek, Mustafa Kavutçu and Mustafa Arslan
ORCID
Author(s) ORCID Number
Cagri Ozdemir http://orcid.org/0000-0002-1266-8054
Aydin Yavuz http://orcid.org/0000-0001-9688-2076
Saban Cem Sezen http://orcid.org/0000-0003-3996-7692
Omer Kurtipek http://orcid.org/0000-0001-8689-062X
Mustafa Kavutçu http://orcid.org/0000-0002-5135-8067
Mustafa Arslan http://orcid.org/0000-0003-4882-5063
Funding Agency and Grant Number
Corresponding Author Cagri Ozdemir, Assistant Professor, Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Mehmet Akif Ersoy mahallesi, YDA Park Avenue Sitesi No:5 N Blok Kat 18 Daire 76, Ankara 06000, Türkiye. cagriozdemir@gazi.edu.tr
Key Words Hepatic ischemia-reperfusion; Fullerenol C60; Desflurane; Oxidative stress; Liver injury
Core Tip Hepatic ischemia-reperfusion injury (IRI) remains a major challenge during liver surgery and transplantation because oxidative stress and inflammation can cause significant tissue damage. This experimental study demonstrated that fullerenol C60 significantly reduced lipid peroxidation, preserved endogenous antioxidant enzyme activity, and improved histopathological liver injury in desflurane-anesthetized rats. Desflurane also provided partial protection, although the combined treatment showed no clear superiority over fullerenol alone. These findings suggest that fullerenol C60 may be a promising adjunctive strategy for limiting hepatic IRI and preserving liver function. Further translational and clinical studies are required to confirm optimal dosing, mechanisms, safety, and therapeutic applicability in humans.
Publish Date 2026-09-17 05:48
Citation

Kasapbasi E, Ozdemir C, Yavuz A, Sezen SC, Kurtipek O, Kavutçu M, Arslan M. Effects of fullerenol C60 on hepatic ischemia-reperfusion injury in desflurane-anesthetized rats. World J Hepatol 2026; 18(9): 122845

URL https://www.wjgnet.com/1948-5182/full/v18/i9/122845.htm
DOI https://doi.org/10.4254/wjh.122845
Full Article (PDF) WJH-18-122845-with-cover.pdf
The ARRIVE Guidelines 122845-The-ARRIVE-Guidelines.pdf
Manuscript File 122845_Auto_Edited_081945.docx
Answering Reviewers 122845-answering-reviewers.pdf
Audio Core Tip 122845-audio.mp3
Biostatistics Review Certificate 122845-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 122845-conflict-of-interest-statement.pdf
Copyright License Agreement 122845-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 122845-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate 122845-non-native-speakers.pdf
Peer-review Report 122845-peer-reviews.pdf
Scientific Misconduct Check 122845-scientific-misconduct-check.png
CrossCheck Report 122845-crosscheck-report.pdf