Publication Name	World Journal of Clinical Cases
Manuscript ID	12285
Country

Received	2014-06-30 10:18
Peer-Review Started	2014-06-30 16:43
To Make the First Decision	2014-09-16 10:51
Return for Revision	2014-09-18 09:26
Revised	2014-09-29 03:58
Second Decision	2014-10-29 17:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-29 18:54
Articles in Press	2014-10-29 18:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-22 09:03
Publish the Manuscript Online	2015-02-05 16:28

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Review
Article Title	State-of-the-Art management of knee osteoarthritis
Manuscript Source	Invited Manuscript
All Author List	Kenton H Fibel, Howard J Hillstrom and Brian C Halpern
Funding Agency and Grant Number
Corresponding Author	Brian C Halpern, MD, Department of Medicine, Primary Care Sports Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, United States. halpernb@hss.edu
Key Words	Disease-modifying osteoarthritis drugs; Knee osteoarthritis; Disease-modifying osteoarthritis drugs; Osteoarthritis management; Non-steroidal anti-inflammatory drugs; Hyaluronic acid; Arthroscopy; Platelet-rich plasma; Corticosteroids; Stem cells
Core Tip	The management of knee osteoarthritis is of growing importance in the world and especially in the United States where an aging population and increasing trends in obesity are increasing the prevalence of this disease. Treatment has traditionally focused on symptom control, however, more recently there has been a greater emphasis placed on developing new modalities that aim to slow disease progression or even reverse the process. This review aims to examine the available literature on such modalities ranging from patient education and weight loss to disease-modifying osteoarthritis drugs to platelet-rich plasma, stem cells, and other emerging injectables.
Publish Date	2015-02-05 16:28
Citation	Fibel KH, Hillstrom HJ, Halpern BC. State-of-the-Art management of knee osteoarthritis. World J Clin Cases 2015; 3(2): 89-101
URL	http://www.wjgnet.com/2307-8960/full/v3/i2/89.htm
DOI	http://dx.doi.org/10.12998/wjcc.v3.i2.89

Full Article (PDF)	WJCC-3-89.pdf
Full Article (Word)	WJCC-3-89.doc
Manuscript File	12285-Review.docx
Answering Reviewers	12285-Answering reviewers.pdf
Copyright License Agreement	12285-Copyright assignment.pdf
Peer-review Report	12285-Peer review(s).pdf
Scientific Misconduct Check	12285-CrossCheck.jpg
Scientific Editor Work List	12285-Scientific editor work list.pdf