Publication Name	World Journal of Rheumatology
Manuscript ID	12291
Country	United States

Received	2014-06-30 20:12
Peer-Review Started	2014-07-01 08:28
To Make the First Decision	2014-07-18 12:34
Return for Revision	2014-07-18 17:20
Revised	2014-08-11 08:11
Second Decision	2015-04-01 15:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-14 15:57
Articles in Press	2015-04-14 15:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-17 16:51
Publish the Manuscript Online	2015-07-08 09:04

ISSN	2220-3214 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Rheumatology
Manuscript Type	Review
Article Title	Pathogenetic mechanisms of antiphospholipid antibody production in antiphospholipid syndrome
Manuscript Source	Invited Manuscript
All Author List	Rohan Willis and Emilio B Gonzalez
Funding Agency and Grant Number
Corresponding Author	Emilio B Gonzalez, MD, FACP, FACR, Director and Chief, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-1165, United States. ebgonzal@utmb.edu
Key Words	Antiphospholipid; Autoimmune; Infections; Antibody production; Susceptibility; Genetic; Human leukocyte antigen; Environmental; Immune tolerance
Core Tip	This article reviews the most up to date theories regarding the production of pathogenic antiphospholipid antibodies (aPL) in antiphospholipid syndrome. It focuses on both the genetic and environmental aspects related to aPL production. The genetic factors highlighted include human leukocyte antigen (HLA) and non-HLA associations and where available, data linking genes to clinical manifestations is presented. The key infectious agents linked to the formation of pathogenic aPL and those mechanisms by which these agents induce a break in immune tolerance are also discussed.
Publish Date	2015-07-08 09:04
Citation	Willis R, Gonzalez EB. Pathogenetic mechanisms of antiphosp¬holipid antibody production in antiphospholipid syndrome. World J Rheumatol 2015; 5(2): 59-68
URL	http://www.wjgnet.com/2220-3214/full/v5/i2/59.htm
DOI	http://dx.doi.org/10.5499/wjr.v5.i2.59

Full Article (PDF)	WJR-5-59.pdf
Full Article (Word)	WJR-5-59.doc
Manuscript File	12291-Review.docx
Answering Reviewers	12291-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12291-Conflict-of-interest statement.pdf
Copyright License Agreement	12291-Copyright assignment.pdf
Peer-review Report	12291-Peer-review(s).pdf
Scientific Misconduct Check	12291-Scientific misconduct check.pdf
Scientific Editor Work List	12291-Scientific editor work list.pdf