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9/1/2026 4:34:33 AM | Browse: 0 | Download: 0
Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 122912
Country India
Received
2026-05-08 06:02
Peer-Review Started
2026-05-08 06:02
First Decision by Editorial Office Director
2026-05-15 11:37
Return for Revision
2026-05-15 11:37
Revised
2026-05-18 10:53
Publication Fee Transferred
Second Decision by Editor
2026-06-01 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-01 09:09
Articles in Press
2026-06-01 09:09
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-01 02:34
Publish the Manuscript Online
2026-09-01 04:34
ISSN 2150-5349 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Correspondence
Article Title Letter to the Editor: Can upadacitinib dose escalation redefine treatment strategies in refractory inflammatory bowel disease?
Manuscript Source Invited Manuscript
All Author List Himanshu Agrawal and Nikhil Gupta
ORCID
Author(s) ORCID Number
Himanshu Agrawal http://orcid.org/0000-0001-7994-2356
Nikhil Gupta http://orcid.org/0000-0001-7265-8168
Funding Agency and Grant Number
Corresponding Author Nikhil Gupta, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, BKS Marg, Delhi 110001, India. nikhil_ms26@yahoo.co.in
Key Words Inflammatory bowel disease; Upadacitinib; Dose escalation; Janus kinase inhibitors; Treatment resistance; Personalized medicine; Ulcerative colitis; Crohn’s disease
Core Tip Upadacitinib dose escalation may provide symptomatic benefit and reduce corticosteroid dependence in selected patients with refractory inflammatory bowel disease who experience secondary loss of response. The findings of Ellington et al support a more flexible and individualized approach to therapeutic optimization while emphasizing the need for careful safety monitoring and prospective validation.
Publish Date 2026-09-01 04:34
Citation

Agrawal H, Gupta N. Letter to the Editor: Can upadacitinib dose escalation redefine treatment strategies in refractory inflammatory bowel disease? World J Gastrointest Pharmacol Ther 2026; 17(3): 122912

URL https://www.wjgnet.com/2150-5349/full/v17/i3/122912.htm
DOI https://doi.org/10.4292/wjgpt.122912
Full Article (PDF) WJGPT-17-122912-with-cover.pdf
Manuscript File 122912_Auto_Edited_013111.docx
Answering Reviewers 122912-answering-reviewers.pdf
Audio Core Tip 122912-audio.mp3
Conflict-of-Interest Disclosure Form 122912-conflict-of-interest-statement.pdf
Copyright License Agreement 122912-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 122912-non-native-speakers.pdf
Peer-review Report 122912-peer-reviews.pdf
Scientific Misconduct Check 122912-scientific-misconduct-check.png
CrossCheck Report 122912-crosscheck-report.pdf