BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/27/2026 6:30:55 AM | Browse: 4 | Download: 2
 |
Received |
|
2026-05-12 05:52 |
|
Peer-Review Started |
|
2026-05-12 05:53 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2026-06-30 06:20 |
|
Revised |
|
2026-07-12 17:23 |
|
Publication Fee Transferred |
|
2026-07-21 08:02 |
|
Second Decision by Editor |
|
2026-07-27 02:43 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-07-28 12:58 |
|
Articles in Press |
|
2026-07-28 12:58 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-10-19 00:18 |
|
Publish the Manuscript Online |
|
2026-10-27 06:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Bile acid metabolic disorders and their role in hepatic encephalopathy of cirrhosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Jie Huo, Zi-Xin Liang, Jing-Xuan Bian, Jing-Tian Zhang, Li Cha, Qi-Yue Yang, Chun-Juan Zhao, Jin-Yu Li, Dui-Ping Feng and Long Gao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Shanxi Provincial Clinical Research Center for Interventional Medicine |
No. 202204010501004 |
| the Central Government Guiding Local Science and Technology Development Funds |
No. YDZJSX20231B010 |
|
| Corresponding Author |
Long Gao, Associate Chief Physician, PhD, Department of Oncological and Vascular Intervention, First Hospital of Shanxi Medical University, No. 56 Xinjian South Road, Yingze District, Taiyuan 030001, Shanxi Province, China. gaolong@sxmu.edu.cn |
| Key Words |
Liver cirrhosis; Bile acids; Hepatic encephalopathy; Gut microbiota; Blood-brain barrier; Gut-liver-brain axis |
| Core Tip |
Cirrhosis disrupts bile acid (BA) homeostasis, creating a vicious cycle with gut dysbiosis and barrier injury. Accumulated toxic BAs cross the blood-brain barrier and modulate neuroinflammation via farnesoid X receptor, Takeda G protein-coupled receptor 5, and Sphingosine-1-phosphate receptor 2 signaling, synergizing with hyperammonemia to drive hepatic encephalopathy. BA profiles vary by cirrhosis etiology, offering diagnostic and prognostic potential. Targeting BA pathways represents a promising therapeutic strategy for hepatic encephalopathy. |
| Publish Date |
2026-10-27 06:30 |
| Citation |
Huo YJ, Liang ZX, Bian JX, Zhang JT, Cha L, Yang QY, Zhao CJ, Li JY, Feng DP, Gao L. Bile acid metabolic disorders and their role in hepatic encephalopathy of cirrhosis. World J Gastroenterol 2026; 32(47): 122954
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i47/122954.htm |
| DOI |
https://doi.org/10.3748/wjg.122954 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
