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Articles Published Processes
9/30/2026 1:50:35 AM | Browse: 2 | Download: 0
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Received |
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2026-05-07 02:14 |
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Peer-Review Started |
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2026-05-07 02:17 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-21 02:15 |
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Revised |
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2026-08-03 03:08 |
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Publication Fee Transferred |
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2026-08-13 13:42 |
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Second Decision by Editor |
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2026-09-10 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-10 09:18 |
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Articles in Press |
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2026-09-10 09:18 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-23 09:06 |
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Publish the Manuscript Online |
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2026-09-30 01:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Observational Study |
| Article Title |
Clonorchis sinensis co-infection potentiates polymorphonuclear-myeloid-derived suppressor cells expansion and metabolic reprogramming in chronic hepatitis B patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie-Ru Qiu, Hong-Bin Zhang, Mei Shang, Jue Xu, Yue-Chun Fu, Yuan Liao, Bo Hu and Hui-Min Dong |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81902082 |
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| Corresponding Author |
Hui-Min Dong, PhD, Researcher, Department of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou 510630, Guangdong Province, China. donghmin@mail.sysu.edu.cn |
| Key Words |
Clonorchis sinensis; Chronic hepatitis B; Hepatitis B virus-Clonorchis sinensis co-infection; Polymorphonuclear myeloid-derived suppressor cell; Ornithine-to-arginine ratio; Immunosuppression |
| Core Tip |
Compared with hepatitis B virus mono-infected patients with normal liver enzyme levels, Clonorchis sinensis co-infection expands polymorphonuclear-myeloid-derived suppressor cells. This activates the arginine (Arg)-ornithine (Orn) axis, raising the Orn-to-Arg ratio. Consequently, interferon-γ production is suppressed. The Orn-to-Arg ratio outperforms standard liver enzyme levels for immune assessment. Screening for Clonorchis sinensis is warranted even in patients with well-controlled viremia. |
| Publish Date |
2026-09-30 01:50 |
| Citation |
Qiu JR, Zhang HB, Shang M, Xu J, Fu YC, Liao Y, Hu B, Dong HM. Clonorchis sinensis co-infection potentiates polymorphonuclear-myeloid-derived suppressor cells expansion and metabolic reprogramming in chronic hepatitis B patients. World J Gastroenterol 2026; 32(44): 122956
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i44/122956.htm |
| DOI |
https://doi.org/10.3748/wjg.122956 |
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