| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Cuproptosis in gastric cancer: Mechanisms and therapeutic opportunities
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Ping Fang, Shu-Ni Liu, Feng-Ping Liu, Jing-Wen Gong, Yi-Fan Zhang, Jun-Hui Lu, Jing-Wei Liu, Qing Wang and Xing Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Construction and Validation of a Prognostic Risk Scoring Model Related to Cuproptosis-Characteristic Genes in Gastric Cancer |
SYYYRC-2022002 |
| Evaluation of the Efficacy and Safety of Different Doses of Saccharomyces boulardii Combined with Dual Regimens for the Eradication of Helicobacter pylori |
ITT-2025-125 |
|
| Corresponding Author |
Xing Chen, MD, Department of Gastroenterology, The First Hospital of Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan 030001, Shanxi Province, China. chen0419xing@163.com |
| Key Words |
Cuproptosis; Copper metabolism; Gastric cancer; Tumor microenvironment; Immunotherapy; Copper ionophores; Copper chelators; Nanomedicine; Biomarkers |
| Core Tip |
Cuproptosis connects copper imbalance with mitochondrial metabolic vulnerability, angiogenesis, immune regulation, and treatment resistance in gastric cancer. This review summarizes copper homeostasis, protein lipoylation, oncogenic signaling, the tumor microenvironment, and copper-modulating therapies. It highlights copper ionophores, chelators, nanomedicine, and biomarkers, including ferredoxin 1, amine oxidase copper-containing 1, integrin beta 1, and serpin family E member 1, for patient stratification and rational combination therapy while emphasizing toxicity and translational challenges. |
| Publish Date |
2026-09-09 09:45 |
| Citation |
Fang YP, Liu SN, Liu FP, Gong JW, Zhang YF, Lu JH, Liu JW, Wang Q, Chen X. Cuproptosis in gastric cancer: Mechanisms and therapeutic opportunities. World J Gastrointest Oncol 2026; 18(9): 123002
|
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i9/123002.htm |
| DOI |
https://doi.org/10.4251/wjgo.123002 |
