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2/7/2015 9:38:00 AM | Browse: 1139 | Download: 1241
Publication Name World Journal of Nephrology
Manuscript ID 12304
Country/Territory United Kingdom
Received
2014-07-01 09:41
Peer-Review Started
2014-07-01 13:38
To Make the First Decision
2014-10-14 17:57
Return for Revision
2014-10-16 18:20
Revised
2014-10-28 00:53
Second Decision
2014-11-12 13:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-19 11:09
Articles in Press
2014-11-19 11:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-01-12 10:04
Publish the Manuscript Online
2015-02-07 09:38
ISSN 2220-6124 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Urology & Nephrology
Manuscript Type Review
Article Title Aging and uremia: Is there cellular and molecular crossover?
Manuscript Source Invited Manuscript
All Author List William E White, Muhammad M Yaqoob and Steven M Harwood
Funding Agency and Grant Number
Corresponding Author Steven M Harwood, PhD, Queen Mary University of London, Translational Medicine and Therapeutics, William Harvey Research Institute, John Vane Science Centre, Charterhouse Square, EC1M 6BQ London, United Kingdom. s.m.harwood@qmul.ac.uk
Key Words Aging; Uremia; Apoptosis; Autophagy; Senescence; Telomeres; Mitochondria; Post-transla­tional protein modification; Klotho
Core Tip This review presents evidence that suggests that the morphological similarities between uremia and physiological aging are underpinned by similarities at a cellular and molecular level. Several of the classical cellular features of aging such as mitochondrial dysfunction and altered proteostasis have been observed in the cells and tissues of uremic humans and animals, and in in vitro models of uremia. There are also many shared features between aging and uremia in terms of cell death and survival pathways. These commonalities may present new targets for the future management of patients with chronic kidney disease.
Publish Date 2015-02-07 09:38
Citation White WE, Yaqoob MM, Harwood SM. Aging and uremia: Is there cellular and molecular crossover? World J Nephrol 2015; 4(1): 19-30
URL http://www.wjgnet.com/2220-6124/full/v4/i1/19.htm
DOI http://dx.doi.org/10.5527/wjn.v4.i1.19
Full Article (PDF) WJN-4-19.pdf
Full Article (Word) WJN-4-19.doc
Manuscript File 12304-Review.docx
Answering Reviewers 12304-Answering reviewers.pdf
Copyright License Agreement 12304-Copyright assignment.pdf
Peer-review Report 12304-Peer review(s).pdf
Scientific Misconduct Check 12304-CrossCheck.jpg
Scientific Editor Work List 12304-Scientific editor work list.pdf