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Articles Published Processes
2/7/2015 9:38:00 AM | Browse: 1306 | Download: 1483
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Received |
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2014-07-01 09:41 |
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Peer-Review Started |
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2014-07-01 13:38 |
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To Make the First Decision |
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2014-10-14 17:57 |
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Return for Revision |
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2014-10-16 18:20 |
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Revised |
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2014-10-28 00:53 |
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Second Decision |
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2014-11-12 13:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-19 11:09 |
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Articles in Press |
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2014-11-19 11:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-12 10:04 |
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Publish the Manuscript Online |
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2015-02-07 09:38 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Review |
| Article Title |
Aging and uremia: Is there cellular and molecular crossover?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
William E White, Muhammad M Yaqoob and Steven M Harwood |
| Funding Agency and Grant Number |
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| Corresponding Author |
Steven M Harwood, PhD, Queen Mary University of London, Translational Medicine and Therapeutics, William Harvey Research Institute, John Vane Science Centre, Charterhouse Square, EC1M 6BQ London,
United Kingdom. s.m.harwood@qmul.ac.uk
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| Key Words |
Aging; Uremia; Apoptosis; Autophagy; Senescence; Telomeres; Mitochondria; Post-translational protein modification; Klotho |
| Core Tip |
This review presents evidence that suggests that the morphological similarities between uremia and physiological aging are underpinned by similarities at a cellular and molecular level. Several of the classical cellular features of aging such as mitochondrial dysfunction and altered proteostasis have been observed in the cells and tissues of uremic humans and animals, and in in vitro models of uremia. There are also many shared features between aging and uremia in terms of cell death and survival pathways. These commonalities may present new targets for the future management of patients with chronic kidney disease.
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| Publish Date |
2015-02-07 09:38 |
| Citation |
White WE, Yaqoob MM, Harwood SM. Aging and uremia: Is there cellular and molecular crossover? World J Nephrol 2015; 4(1): 19-30 |
| URL |
http://www.wjgnet.com/2220-6124/full/v4/i1/19.htm |
| DOI |
http://dx.doi.org/10.5527/wjn.v4.i1.19 |
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