| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Induced pluripotent stem cells in Hirschsprung disease: Modeling, mechanisms, and translational challenges
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yuan-Xiang Qiu, Zheng-Ke Zhi, Yu-Mu Leng, Xin-Tao Zhang, Chun-Xia Du, Jie Tang, Hong-Xing Li and Wei-Bing Tang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82001590, 82270540 |
|
| Corresponding Author |
Hong-Xing Li, Associate Professor, MD, PhD, Department of Pediatric Surgery, Children’s Hospital of Nanjing Medical University, No. 72 Guangzhou Road, Nanjing 210008, Jiangsu Province, China. hx8817@njmu.edu.cn |
| Key Words |
Hirschsprung disease; Induced pluripotent stem cells; Disease modeling; Drug screening; Cell therapy |
| Core Tip |
Patient-derived induced pluripotent stem cell (iPSC) platforms provide human models for linking Hirschsprung disease (HSCR)-associated genetic backgrounds with enteric neural crest cell (ENCC) developmental phenotypes and tissue-level interactions. This review summarizes iPSC platform establishment, two-dimensional ENCC models, recombined and bioengineered gut systems, drug screening, and cell-based regenerative strategies. We emphasize genetic complexity, reproducibility, functional maturation, electrophysiological validation, and translational feasibility. Current iPSC-based HSCR models are most useful for mechanistic investigation and preclinical development, whereas drug screening and cell therapy remain exploratory. |
| Publish Date |
2026-08-20 06:54 |
| Citation |
Qiu YX, Zhi ZK, Leng YM, Zhang XT, Du CX, Tang J, Li HX, Tang WB. Induced pluripotent stem cells in Hirschsprung disease: Modeling, mechanisms, and translational challenges. World J Stem Cells 2026; 18(8): 123046
|
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i8/123046.htm |
| DOI |
https://doi.org/10.4252/wjsc.123046 |
