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Articles Published Processes
7/24/2026 7:03:48 AM | Browse: 3 | Download: 1
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Received |
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2026-05-08 06:38 |
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Peer-Review Started |
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2026-05-08 06:38 |
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First Decision by Editorial Office Director |
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2026-06-08 09:50 |
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Return for Revision |
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2026-06-09 11:57 |
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Revised |
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2026-06-18 15:03 |
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Publication Fee Transferred |
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2026-06-30 13:36 |
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Second Decision by Editor |
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2026-07-07 03:11 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-07 06:38 |
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Articles in Press |
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2026-07-07 06:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-17 01:35 |
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Publish the Manuscript Online |
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2026-07-24 07:03 |
| ISSN |
1948-5182 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Effects of pegylated interferon on T cell receptor fingerprints in chronic hepatitis B patients with/without surface antigen clearance
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kun-Yan Hao, Lei Tang, Guo-Bing Chen, Wei Guo, Zhan-Hui Wang, Li-Peng Mao and Yue-Cheng Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science Foundation of Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University |
22JCYYYB11 |
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| Corresponding Author |
Yue-Cheng Yu, PhD, Center of Hepatology and Department of Infectious Disease, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 34 Yang-Gong-Jing, Qin-Huai Region, Nanjing 210002, Jiangsu Province, China. gslsycy@163.com |
| Key Words |
Hepatitis B surface antigen clearance; Pegylated interferon α-2b; T cell receptor diversity; Complementarity-determining region 3; RNA sequencing; Fingerprints |
| Core Tip |
This study compared T cell receptor (TCR) fingerprints of chronic hepatitis B (CHB) patients with or without hepatitis B surface antigen (HBsAg) clearance following treatment with nucleos(t)ide analogues combined with pegylated interferon alpha-2b (PegIFNα-2b). No baseline virological/biochemical differences was found between the groups. Patients achieving HBsAg clearance exhibited markedly higher TCR α/β chain diversity, more unique clonotypes and greater repertoire overlap. These immune signatures may serve as potential reference indicators for PegIFNα-2b treatment response in CHB patients. |
| Publish Date |
2026-07-24 07:03 |
| Citation |
Hao KY, Tang L, Chen GB, Guo W, Wang ZH, Mao LP, Yu YC. Effects of pegylated interferon on T cell receptor fingerprints in chronic hepatitis B patients with/without surface antigen clearance. World J Hepatol 2026; 18(7): 123089
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i7/123089.htm |
| DOI |
https://doi.org/10.4254/wjh.123089 |
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