| Category |
Oncology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Segment-specific patterns of regional lymph-node metastasis in primary small-cell carcinoma of the esophagus: A systematic review and meta-analysis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ke-Xun Li, Jie Mao, Jian-Zhe Zhang, Zi-Long Qian, Yong-Tao Han and Xue-Feng Leng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the International Cooperation Projects of the Science and Technology Department of Sichuan Province |
2026YFHZ0053 |
| the Ministry of Industry and Information Technology (MIIT) “Open Competition (Jiebang Guashuai) Program” for AI Medical Device Innovation |
2025-AISJK-01001 |
| and The “Flagship” Department Project of Integrated Traditional Chinese and Western Medicine and Yunnan Provincial Department of Science and Technology-Kunming Medical University Special Projects |
202601AY07001-170 and 202601AY07001-179 |
|
| Corresponding Author |
Yong-Tao Han, Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, China., Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China (Sichuan Cancer Hospital), Chengdu, China., 519 Kunzhou Road, Xishan District, Kunming City, Yunnan Province, China., Chengdu 610041, Sichuan Province, China. docyongtaohan@163.com |
| Key Words |
Small-cell carcinoma of the esophagus; Lymph-node metastasis; Nodal stations; Systematic review |
| Core Tip |
In small-cell carcinoma of the esophagus (SCCE), lymph-node metastasis is common and anatomically widespread rather than confined to peritumoral stations. Across four surgical cohorts, the pooled prevalence of pathologic nodal metastasis was 61.1%, with a consistent node-level metastatic ratio of about 11%-13%. Station-level evidence shows segment-specific but bidirectional spread involving cervical, mediastinal, and abdominal compartments, with frequent recurrent laryngeal nerve and perigastric node involvement and non-negligible skip metastasis. These findings highlight that SCCE should be understood as a highly lymphotropic disease and support broader, segment-adapted nodal assessment and clinical target-volume design rather than limited local field assumptions. |
| Publish Date |
2026-08-24 09:20 |
| Citation |
Li KX, Mao J, Zhang JZ, Qian ZL, Han YT, Leng XF. Segment-specific patterns of regional lymph-node metastasis in primary small-cell carcinoma of the esophagus: A systematic review and meta-analysis. World J Clin Oncol 2026; 17(8): 123094
|
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i8/123094.htm |
| DOI |
https://doi.org/10.5306/wjco.123094 |
