BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/20/2026 3:52:41 AM | Browse: 0 | Download: 0
 |
Received |
|
2026-05-13 07:13 |
|
Peer-Review Started |
|
2026-05-13 07:14 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2026-06-29 08:27 |
|
Revised |
|
2026-06-30 15:00 |
|
Publication Fee Transferred |
|
2026-07-06 12:10 |
|
Second Decision by Editor |
|
2026-07-24 03:17 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-07-28 12:55 |
|
Articles in Press |
|
2026-07-28 12:55 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-10-09 02:53 |
|
Publish the Manuscript Online |
|
2026-10-20 03:52 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Minireviews |
| Article Title |
Antibiotic-associated gut dysbiosis and intestinal failure in critically ill patients: Mechanisms and interventions
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Liang Tian and Shan-Shan Xu |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Liang Tian, Associate Faculty, Chief Pharmacist, Department of Pharmacy, Shanghai Deji Hospital, Qingdao University Shanghai Clinical Medical College, No. 378 Gulang Road, Putuo District, Shanghai 200331, China. tianliang@shneuro.org |
| Key Words |
Anti-bacterial agents; Gut microbiota dysbiosis; Critically ill patients; Intestinal failure; Short-chain fatty acids; Molecular mechanisms; Antibiotic stewardship |
| Core Tip |
Broad-spectrum antibiotics precipitate a four-stage pathological cascade in critically ill patients: Gut microbiota dysbiosis, short-chain fatty acid depletion, intestinal barrier injury, and systemic inflammatory activation, ultimately driving multiple organ dysfunction syndrome. This review maps each cascade stage to a specific intervention, proposing a stage-based therapeutic framework. Three clinical priorities: Microbiome surveillance after prolonged antibiotic exposure, early enteral nutrition within 48 hours, and integration of days-of-therapy/antibiotic spectrum index metrics into stewardship decisions. |
| Publish Date |
2026-10-20 03:52 |
| Citation |
Tian L, Xu SS. Antibiotic-associated gut dysbiosis and intestinal failure in critically ill patients: Mechanisms and interventions. World J Gastroenterol 2026; 32(46): 123234
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i46/123234.htm |
| DOI |
https://doi.org/10.3748/wjg.123234 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
