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Publication Name World Journal of Diabetes
Manuscript ID 123276
Country Taiwan
Received
2026-05-13 01:40
Peer-Review Started
2026-05-13 23:59
First Decision by Editorial Office Director
2026-06-02 07:15
Return for Revision
2026-06-02 07:15
Revised
2026-06-15 16:38
Publication Fee Transferred
Second Decision by Editor
2026-06-30 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-07-08 09:01
Articles in Press
2026-07-08 09:01
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-08-26 00:30
Publish the Manuscript Online
2026-09-04 05:57
ISSN 1948-9358 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Obstetrics & Gynecology
Manuscript Type Retrospective Cohort Study
Article Title Early risk stratification of gestational diabetes using interpretable machine learning with first-trimester screening parameters
Manuscript Source Unsolicited Manuscript
All Author List Shuo-Mei Hung, Chie-Pein Chen, Fang-Ju Sun, Yi-Yung Chen, Liang-Kai Wang and Chen-Yu Chen
ORCID
Author(s) ORCID Number
Chen-Yu Chen http://orcid.org/0000-0003-4519-8391
Funding Agency and Grant Number
Funding Agency Grant Number
National Science and Technology Council of Taiwan No. NSTC 113-2314-B-195-016-MY3
Corresponding Author Chen-Yu Chen, Full Professor, MD, PhD, Department of Obstetrics and Gynecology, MacKay Memorial Hospital, No. 92, Section 2 Zhongshan North Road, Taipei 104217, Taiwan. f122481@mmh.org.tw
Key Words Gestational diabetes mellitus; Machine learning; First trimester; Risk stratification; Pregnancy-associated plasma protein A; Placental growth factor
Core Tip This retrospective cohort study developed an interpretable machine learning model for early risk stratification of gestational diabetes mellitus using first-trimester clinical and biomarker parameters. In 2756 pregnancies, gradient boosting with random oversampling achieved moderate discrimination with high negative predictive value. Model interpretation using SHapley Additive exPlanations and patient-level heatmaps identified maternal and placental factors as key contributors. This approach may support early identification of at-risk women and facilitate targeted preventive strategies before routine mid-pregnancy screening.
Publish Date 2026-09-04 05:57
Citation

Hung SM, Chen CP, Sun FJ, Chen YY, Wang LK, Chen CY. Early risk stratification of gestational diabetes using interpretable machine learning with first-trimester screening parameters. World J Diabetes 2026; 17(9): 123276

URL https://www.wjgnet.com/1948-9358/full/v17/i9/123276.htm
DOI https://doi.org/10.4239/wjd.123276
Full Article (PDF) WJD-17-123276-with-cover.pdf
STROBE Statement 123276-STROBE-statement.pdf
Manuscript File 123276_Auto_Edited_011532.docx
Answering Reviewers 123276-answering-reviewers.pdf
Audio Core Tip 123276-audio.mp3
Biostatistics Review Certificate 123276-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 123276-conflict-of-interest-statement.pdf
Copyright License Agreement 123276-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 123276-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 123276-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 123276-non-native-speakers.pdf
Supplementary Material 123276-supplementary-material.pdf
Peer-review Report 123276-peer-reviews.pdf
Journal Editor-in-Chief Review Report 123276-journal-editor-in-chief.pdf
Scientific Misconduct Check 123276-scientific-misconduct-check.png