BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/12/2026 6:27:06 AM | Browse: 1 | Download: 0
 |
Received |
|
2026-05-20 00:31 |
|
Peer-Review Started |
|
2026-05-24 23:55 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2026-06-29 06:59 |
|
Revised |
|
2026-07-11 03:38 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-08-11 03:23 |
|
Second Decision by Editor-in-Chief |
|
2026-08-17 01:39 |
|
Final Decision by Editorial Office Director |
|
2026-09-04 09:33 |
|
Articles in Press |
|
2026-09-04 09:33 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-09-10 09:49 |
|
Publish the Manuscript Online |
|
2026-10-12 06:27 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Exosomes as emerging mediators and therapeutic vehicles in painful diabetic neuropathy: From pathophysiology to clinical translation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Idris Long and Entesar Yaseen Abdo Qaid |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundamental Research Grant Scheme of the Ministry of Higher Education, Malaysia |
No. FRGS/1/2024/SKK10/USM/02/8 |
|
| Corresponding Author |
Idris Long, Associate Professor, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Jalan Raja Perempuan Zainab, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia. idriskk@usm.my |
| Key Words |
Exosomes; Extracellular vesicles; Painful diabetic neuropathy; Neuropathic pain; MicroRNA; Mesenchymal stem cells; Neuroinflammation; Biomarkers; Nanoparticle drug delivery; Central sensitization |
| Core Tip |
Exosomes play a central role in painful diabetic neuropathy (PDN) by mediating pathological intercellular signaling while also serving as promising therapeutic vehicles targeting neuroinflammation, axonal degeneration, and pain sensitization. Circulating exosomal microRNA and protein signatures are promising candidate biomarkers, but their clinical application is currently limited by the lack of standardized reference ranges, unresolved specificity across diabetic complications, and confounding effects of diabetic nephropathy, requiring validation in large prospective studies. Likewise, mesenchymal stem cell-derived and engineered exosomes demonstrate robust therapeutic efficacy and neuroprotective effects in preclinical PDN models; however, no clinical trials have yet evaluated these approaches in PDN patients, underscoring the need for clinical translation before they can be considered disease-modifying therapies. |
| Publish Date |
2026-10-12 06:27 |
| Citation |
Long I, Abdo Qaid EY. Exosomes as emerging mediators and therapeutic vehicles in painful diabetic neuropathy: From pathophysiology to clinical translation. World J Diabetes 2026; 17(10): 123286
|
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i10/123286.htm |
| DOI |
https://doi.org/10.4239/wjd.123286 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
