Publication Name	World Journal of Gastroenterology
Manuscript ID	12330
Country	Taiwan

Received	2014-07-03 10:00
Peer-Review Started	2014-07-03 14:15
First Decision by Editorial Office Director
Return for Revision	2014-07-23 15:04
Revised	2014-10-25 14:32
Publication Fee Transferred
Second Decision by Editor	2014-12-16 15:28
Second Decision by Editor-in-Chief	2014-12-17 03:13
Final Decision by Editorial Office Director	2014-12-22 17:04
Articles in Press	2014-12-22 17:24
Edit the Manuscript by Language Editor	2015-01-23 08:39
Typeset the Manuscript	2015-03-25 20:11
Publish the Manuscript Online	2015-04-15 11:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells
Manuscript Source	Invited Manuscript
All Author List	Cheng-Chia Tsai, Tang-Wei Chuang, Li-Jen Chen, Ho-Shan Niu, Kun-Ming Chung, Juei-Tang Cheng and Kao-Chang Lin
Funding Agency and Grant Number	Funding Agency Grant Number Chi Mei Medical Center in Taiwan CMFHR10302(partly)
Corresponding Author	Juei-Tang Cheng, PhD, FCP, Professor, Institute of Medical Sciences, Chang Jung Christian University, Geuiren, Tainan City 71101, Taiwan. jtcheng@mail.cjcu.edu.tw
Key Words	Silibinin; Metformin; COLO 205; Mammol/Lalian target of rapamycin; Apoptosis; Colorectal cancer
Core Tip	Silibinin is known to provide protection against hepatotoxic stress. Silibinin has also been shown to have high efficacy against cancer cells through increased expression of the phosphatase and tensin homolog; Metformin, a well-known antidiabetic agent, has recently been reported to inhibit cancer by increasing adenosine monophosphate-activated protein kinase expression. We investigated the effect of metformin on silibinin-induced apoptosis in human colorectal cancer cells. The combined treatment of human colorectal cancer cells with silibinin and metformin may induce apoptosis at a dose that does not affect human colonic epithelial cells. This finding reveals a potential therapeutic strategy for the treatment of colorectal cancer.
Publish Date	2015-04-15 11:01
Citation	Tsai CC, Chuang TW, Chen LJ, Niu HS, Chung KM, Cheng JT, Lin KC. Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells. World J Gastroenterol 2015; 21(14): 4169-4177
URL	http://www.wjgnet.com/1007-9327/full/v21/i14/4169.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i14.4169

Full Article (PDF)	WJG-21-4169.pdf
Full Article (Word)	WJG-21-4169.doc
Manuscript File	12330-Review.doc
Answering Reviewers	12330-Answering reviewers.pdf
Copyright License Agreement	12330-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12330-Language certificate.pdf
Peer-review Report	12330-Peer review(s).pdf
Scientific Misconduct Check	12330-CrossCheck.jpg
Scientific Editor Work List	12330-Scientific editor work list.pdf