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Articles Published Processes
8/20/2026 6:49:54 AM | Browse: 2 | Download: 0
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Received |
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2026-05-18 08:10 |
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Peer-Review Started |
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2026-05-18 08:10 |
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First Decision by Editorial Office Director |
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2026-05-26 09:49 |
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Return for Revision |
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2026-05-26 10:40 |
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Revised |
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2026-06-18 21:12 |
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Publication Fee Transferred |
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2026-07-16 03:27 |
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Second Decision by Editor |
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2026-08-05 03:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-05 10:46 |
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Articles in Press |
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2026-08-05 10:46 |
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Edit the Manuscript by Language Editor |
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2026-08-07 15:01 |
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Typeset the Manuscript |
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2026-08-13 05:48 |
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Publish the Manuscript Online |
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2026-08-20 06:49 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Large cell neuroendocrine carcinoma of the distal common bile duct: A case report and review of literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo-Qian Zheng, Ze-Pu Wang, Rui-Zeng Feng, Ze-Cun Zheng, Hong-Jie Wang, Hao Wang and Hong-Fang Tuo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hong-Fang Tuo, Associate Professor, Second Department of Hepatobiliary and Pancreatic Surgery, Hebei Provincial People's Hospital, No.348 Heping West Road, Xinhua District, Shijiazhuang City, Hebei Province, P.R. China, Shijiazhuang 050051, Hebei Province, China. tuohongfang2023@163.com |
| Key Words |
Neuroendocrine carcinoma; Common bile duct; Pancreaticoduodenectomy; Multidisciplinary team; Case report |
| Core Tip |
This case reports describe a distal common bile duct large cell neuroendocrine carcinoma (LCNEC) with a positive bile duct margin (R1 resection). Comprehensive immunohistochemistry revealed a proficient mismatch repair (MMR)/microsatellite stable phenotype, providing a molecular basis for excluding postoperative adjuvant immunotherapy. It is the first report of MMR testing directly guiding treatment decisions in biliary LCNEC, and clinicians are advised to incorporate MMR testing as a routine examination for biliary neuroendocrine carcinoma to inform immunotherapy decisions. With effective systemic therapy, positive margin (R1) resection does not preclude the possibility of favorable short-term outcomes. Multidisciplinary management that integrates molecular pathology is key to individualized treatment of rare tumors. |
| Publish Date |
2026-08-20 06:49 |
| Citation |
Zheng BQ, Wang ZP, Feng RZ, Zheng ZC, Wang HJ, Wang H, Tuo HF. Large cell neuroendocrine carcinoma of the distal common bile duct: A case report and review of literature. World J Clin Cases 2026; 14(24): 123303
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| URL |
https://www.wjgnet.com/2307-8960/full/v14/i24/123303.htm |
| DOI |
https://doi.org/10.12998/wjcc.123303 |
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