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Articles Published Processes
8/24/2026 9:20:53 AM | Browse: 0 | Download: 0
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Received |
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2026-05-20 07:37 |
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Peer-Review Started |
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2026-05-20 07:37 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-10 03:16 |
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Revised |
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2026-07-15 10:32 |
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Publication Fee Transferred |
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2026-07-28 01:41 |
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Second Decision by Editor |
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2026-08-13 02:29 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-14 09:33 |
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Articles in Press |
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2026-08-14 09:33 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-20 01:20 |
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Publish the Manuscript Online |
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2026-08-24 09:20 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Genomic landscape and clinical actionability of renal cell carcinoma in an Indian cohort: A real-world targeted next-generation sequencing study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Vineet Talwar, Arpit Jain, Varun Goel, Bhumi Agarwal, Prateek Gupta, Rupal Tripathi, Sudhir Rawal and Anurag Mehta |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Arpit Jain, Consultant, Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector -5, Rohini, New Delhi 110085, India. jain.arpit@rgcirc.org |
| Key Words |
Clear cell renal cell carcinoma; Next-generation sequencing; Precision oncology; Real-world data; European Society for Medical Oncology Scale for Clinical Actionability of Molecular Targets |
| Core Tip |
Renal cell carcinoma (RCC) demonstrates significant molecular heterogeneity; however, genomic data from Indian patients remain limited. In this real-world single-center study, targeted next-generation sequencing identified recurrent alterations in VHL, PBRM1, SETD2, ATM, and TP53, with concurrent VHL-PBRM1 mutations representing the most frequent co-alteration pattern. Potentially actionable alterations, primarily involving the PI3K-AKT-mTOR pathway, were detected in a subset of patients based on the European Society for Medical Oncology Scale for Clinical Actionability of Molecular Targets. These findings provide important insights into the genomic profile and therapeutic implications of RCC in an underrepresented population. |
| Publish Date |
2026-08-24 09:20 |
| Citation |
Talwar V, Jain A, Goel V, Agarwal B, Gupta P, Tripathi R, Rawal S, Mehta A. Genomic landscape and clinical actionability of renal cell carcinoma in an Indian cohort: A real-world targeted next-generation sequencing study. World J Clin Oncol 2026; 17(8): 123328
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| URL |
https://www.wjgnet.com/2218-4333/full/v17/i8/123328.htm |
| DOI |
https://doi.org/10.5306/wjco.123328 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
