Publication Name	World Journal of Gastroenterology
Manuscript ID	12334
Country	China

Received	2014-07-03 09:40
Peer-Review Started	2014-07-03 15:32
To Make the First Decision	2014-07-21 13:00
Return for Revision	2014-07-23 15:40
Revised	2014-08-19 01:14
Second Decision	2014-10-15 12:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-15 17:46
Articles in Press	2014-10-15 18:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-10-25 22:01
Typeset the Manuscript	2014-12-25 21:34
Publish the Manuscript Online	2015-01-07 11:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Fan-Di Meng, Ji-Chao Wei, Kai Qu, Zhi-Xin Wang, Qi-Fei Wu, Ming-Hui Tai, Hao-Chen Liu, Rui-Yao Zhang and Chang Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30872482 National Natural Science Foundation of China 81072051
Corresponding Author	Chang Liu, MD, PhD, Professor, Department of Hepatobiliary Surgery, the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, 277 West Yan-ta Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Key Words	Forkhead box protein M1; Epithelial-mesenchymal transition; Hepatocellular carcinoma; Snail homolog 1; E-cadherin
Core Tip	Epithelial-mesenchymal transition (EMT) has emerged as a pivotal event affecting cancer invasion and metastasis, and forkhead box protein M1 (FoxM1) may regulate the EMT phenotype of pancreatic cancer cells by activation of mesenchymal cell markers. The present study demonstrated that FoxM1 plays a pivotal role in EMT and metastasis of hepatocellular carcinoma (HCC). Immunohistochemical analysis indicated that FoxM1 overexpression correlated significantly with HCC metastasis and EMT. In vitro, we found that FoxM1 plays a key role in HGF-induced EMT, and overexpression of FoxM1 could suppress E-cadherin expression and induce EMT changes by increasing snail homologue 1 expression.
Publish Date	2015-01-07 11:07
Citation	Meng FD, Wei JC, Qu K, Wang ZX, Wu QF, Tai MH, Liu HC, Zhang RY, Liu C. FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma. World J Gastroenterol 2015; 21(1): 196-213
URL	http://www.wjgnet.com/1007-9327/full/v21/i1/196.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i1.196

Full Article (PDF)	WJG-21-196.pdf
Full Article (Word)	WJG-21-196.doc
Manuscript File	12334-Review.doc
Answering Reviewers	12334-Answering reviewers.pdf
Copyright License Agreement	12334-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12334-Language certificate.pdf
Peer-review Report	12334-Peer reviews.pdf
Scientific Misconduct Check	12334-CrossCheck.jpg
Scientific Editor Work List	12334-Scientific editor work list.pdf