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Articles Published Processes
11/9/2026 4:15:49 AM | Browse: 1 | Download: 1
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Received |
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2026-05-25 07:18 |
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Peer-Review Started |
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2026-05-25 07:18 |
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First Decision by Editorial Office Director |
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2026-06-12 09:25 |
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Return for Revision |
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2026-06-23 07:09 |
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Revised |
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2026-07-24 13:02 |
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Publication Fee Transferred |
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2026-08-12 04:07 |
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Second Decision by Editor |
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2026-09-08 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-08 09:36 |
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Articles in Press |
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2026-09-08 09:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-20 12:58 |
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Publish the Manuscript Online |
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2026-11-09 04:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Identification of region-specific signaling modules governing Crohn’s pathogenesis via mass spectrometry-based integrative acetyl-proteomics
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Jing Guo, Jing Wen, Jing-Xia Liu, Yi-Ning Gao and Xin-Wang Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82405585 |
| Henan Province Science and Technology Research Project |
No. 252102311264 |
| Henan Higher Education Key Research Project |
No. 23A360019 |
| China Postdoctoral Science Foundation |
No. 2025M773941 |
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| Corresponding Author |
Xin-Wang Chen, Director, Head, PhD, Professor, School of Acupuncture-Moxibustion and Tuina, Henan University of Chinese Medicine, No. 156 Jinshui East Road, Zhengdong New District, Zhengzhou 450046, Henan Province, China. 787746907@qq.com |
| Key Words |
Crohn’s disease; Lysine acetylation; Proteomics; Histone modification; Regional heterogeneity; Gut microbiota; Nuclear factor kappa-B signaling; 2,4,6-trinitrobenzenesulfonic acid-induced colitis |
| Core Tip |
This study presents a segment-resolved acetyl-proteomic landscape in a rat model of Crohn’s disease, revealing distinct acetylation signatures across the proximal, mid, and distal colon. Fifteen hub proteins, including receptor-interacting serine/threonine-protein kinase 2, signal transducer and activator of transcription 1, nuclear factor kappa B subunit 2, Ywhaz and SMRD2 were identified from the acetyl-protein interaction network. Site-specific validation by parallel reaction monitoring confirmed the reliability of the discovery proteomics. These region-specific acetylation patterns and hub proteins provide a foundation for biomarker discovery and targeted therapeutic strategies in Crohn’s disease. |
| Publish Date |
2026-11-09 04:15 |
| Citation |
Guo YJ, Wen J, Liu JX, Gao YN, Chen XW. Identification of region-specific signaling modules governing Crohn’s pathogenesis via mass spectrometry-based integrative acetyl-proteomics. World J Gastroenterol 2027; 33(1): 123358
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| URL |
https://www.wjgnet.com/1007-9327/full/v33/i1/123358.htm |
| DOI |
https://doi.org/10.3748/wjg.123358 |
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