| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Clinical features and biomarkers associated with ulcerative colitis: A systematic review and meta-analysis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kai Liu, Xiao-Han Zhang, Xiang-Yu Zhou, Yu-Xuan Liu, Shi-Qi Pan, Ting-Xiu Liu, Robb Russell, Xue-Hui Wang, Yu-Pu Yao, Xing-Jie Zhao, Hui-Yi Sun, Chuan-Lan Ju, Jian-Ping Liu and Zhao-Lan Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82374298 |
|
| Corresponding Author |
Zhao-Lan Liu, PhD, Professor, Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, No. 11 East Road of North Third Ring Road, Chaoyang District, Beijing 100029, China. lzl1019@163.com |
| Key Words |
Ulcerative colitis; Meta-analysis; Clinical features; Biomarkers; Association strengths |
| Core Tip |
This systematic meta-analysis quantifies the associations of non-invasive clinical features and laboratory biomarkers with ulcerative colitis (UC). Based on 389 studies, bloody mucopurulent stools and tenesmus are strongly associated with UC, while perianal fistulae and abdominal masses link more directly to Crohn’s disease. Furthermore, fecal calprotectin, erythrocyte sedimentation rate, and C-reactive protein show significant associations with UC activity and differential risks. Mapping these clinical and biomarker associations offers an evidence-based framework to optimize patient prioritization for invasive endoscopy. |
| Publish Date |
2026-10-20 03:52 |
| Citation |
Liu K, Zhang XH, Zhou XY, Liu YX, Pan SQ, Liu TX, Russell R, Wang XH, Yao YP, Zhao XJ, Sun HY, Ju CL, Liu JP, Liu ZL. Clinical features and biomarkers associated with ulcerative colitis: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(46): 123374
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i46/123374.htm |
| DOI |
https://doi.org/10.3748/wjg.123374 |
