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Articles Published Processes
8/5/2026 7:53:18 AM | Browse: 1 | Download: 0
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Received |
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2026-05-22 10:58 |
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Peer-Review Started |
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2026-05-31 23:57 |
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First Decision by Editorial Office Director |
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2026-07-01 04:00 |
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Revised |
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2026-07-07 14:15 |
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2026-07-24 09:08 |
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Second Decision by Editor |
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2026-07-31 02:50 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-31 09:40 |
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Articles in Press |
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2026-07-31 09:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-04 00:16 |
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Publish the Manuscript Online |
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2026-08-05 07:53 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Lin Lu, Fang Yu, Hai-Feng Zhou, Ping Hu and Sheng-Lian Gan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sheng-Lian Gan, Chief Physician, Department of Endocrinology and Metabolism, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 388 Renmin East Road, Changde 415003, Hunan Province, China. ganshenglian03@126.com |
| Key Words |
Comorbid osteoporosis; Diabetes mellitus; Bone metabolic markers; Risk determinants; Parathyroid hormone |
| Core Tip |
Type 2 diabetes (T2DM) is associated with impaired bone quality and an increased risk of fractures. However, assessment based solely on bone density has important limitations. In this retrospective study, patients with T2DM and osteoporosis (OP) exhibited higher serum parathyroid hormone (PTH) and β-C-terminal telopeptide of type I collagen levels than those without OP, suggesting altered bone metabolism. Notably, PTH concentrations in the OP group were more than double those in the non-OP group and were accompanied by evidence of reduced skeletal responsiveness to PTH. Multivariate analysis further identified older age and elevated PTH levels as independent risk factors for OP comorbidity. These findings suggest that routine assessment of PTH and β-C-terminal telopeptide of type I collagen, combined with clinical evaluation, may facilitate the earlier identification of high-risk T2DM patients, thereby enabling early intervention before the occurrence of fragility fractures. |
| Publish Date |
2026-08-05 07:53 |
| Citation |
Lu HL, Yu F, Zhou HF, Hu P, Gan SL. Clinical significance of bone metabolic markers in osteoporosis-complicated type 2 diabetes mellitus and risk determinants: A retrospective study. World J Diabetes 2026; 17(8): 123389
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i8/123389.htm |
| DOI |
https://doi.org/10.4239/wjd.123389 |
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