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Articles Published Processes
10/10/2026 9:09:52 AM | Browse: 1 | Download: 0
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Received |
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2026-05-20 08:10 |
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Peer-Review Started |
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2026-05-20 08:10 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-06 11:31 |
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Revised |
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2026-07-18 15:16 |
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Publication Fee Transferred |
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2026-08-01 09:21 |
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Second Decision by Editor |
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2026-08-19 02:56 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-20 08:44 |
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Articles in Press |
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2026-08-20 08:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-22 09:06 |
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Publish the Manuscript Online |
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2026-10-10 09:09 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Review |
| Article Title |
Muscle-brain endocrine axis in autism spectrum disorder: Mechanisms, evidence, and research priorities
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rui-Yin Guo and Wen-Cong Geng |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Rui-Yin Guo, Lecturer, Department of Basic Courses, Qilu Institute of Technology, No. 3028 Jingshi East Road, Jinan 250200, Shandong Province, China. guoruiin@163.com |
| Key Words |
Autism spectrum disorder; Skeletal muscle; Muscle-brain axis; Myokines; Irisin; Brain-derived neurotrophic factor; Neuroplasticity; Exercise intervention |
| Core Tip |
This review evaluates skeletal muscle-brain communication as a hypothesis-generating framework for autism spectrum disorder. It distinguishes autism-specific evidence from mechanistic findings derived from other disease models, addresses the brain-derived neurotrophic factor paradox, and emphasizes that the proposed links among irisin, interleukin-6, neuroplasticity, neuroinflammation, metabolism, and stress regulation vary substantially in evidential strength. Current data do not justify biomarker-guided exercise prescriptions or myokine-targeted therapy in clinical practice. Instead, the framework identifies testable mechanisms, major translational gaps, and priorities for stratified randomized trials. |
| Publish Date |
2026-10-10 09:09 |
| Citation |
Guo RY, Geng WC. Muscle-brain endocrine axis in autism spectrum disorder: Mechanisms, evidence, and research priorities. World J Psychiatry 2026; 16(10): 123438
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| URL |
https://www.wjgnet.com/2220-3206/full/v16/i10/123438.htm |
| DOI |
https://doi.org/10.5498/wjp.123438 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
