BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/9/2026 4:15:46 AM | Browse: 1 | Download: 1
 |
Received |
|
2026-05-20 07:52 |
|
Peer-Review Started |
|
2026-05-20 07:52 |
|
First Decision by Editorial Office Director |
|
2026-06-04 09:04 |
|
Return for Revision |
|
2026-06-04 09:04 |
|
Revised |
|
2026-06-15 09:38 |
|
Publication Fee Transferred |
|
2026-06-20 13:15 |
|
Second Decision by Editor |
|
2026-07-02 02:34 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-07-02 08:48 |
|
Articles in Press |
|
2026-07-02 08:48 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-09-14 03:08 |
|
Publish the Manuscript Online |
|
2026-11-09 04:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Identification of UPB1 as a tumor suppressor associated with immune infiltration in cholangiocarcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhong-Hai Sun, Bi-Cheng Zeng, Jia Sun, Bing-Lu Li and Zu-Yi Ma |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Promotion Program for Clinical Medicine |
No. 2025CMFA08 |
| Beijing Bethune Charitable Foundation |
No. GDZL040 |
| Postdoctoral Fellowship Program of China Postdoctoral Science Foundation |
No. GZC20251430 |
| Sun Yat-sen Pilot Scientific Research Fund |
No. YXQH202608 |
|
| Corresponding Author |
Zu-Yi Ma, Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, No. 107 Yanjiang West Road, Yuexiu District, Guangzhou 510000, Guangdong Province, China. 13076335286@163.com |
| Key Words |
UPB1; Cholangiocarcinoma; Tumor suppressor; Immune infiltration; Cell cycle; Apoptosis |
| Core Tip |
This study identifies UPB1 as a tumor suppressor in cholangiocarcinoma (CCA). The expression of UPB1 is downregulated in CCA and correlates with adverse clinical features and worse survival. UPB1 overexpression enhances cell apoptosis and triggers G1/S phase arrest. UPB1 expression shows a positive correlation with tumor-infiltrating lymphocytes, and UPB1 overexpression promotes T-cell activation and immune factor release. UPB1 represents a novel prognostic biomarker and a candidate for further investigation in CCA. |
| Publish Date |
2026-11-09 04:15 |
| Citation |
Sun ZH, Zeng BC, Sun J, Li BL, Ma ZY. Identification of UPB1 as a tumor suppressor associated with immune infiltration in cholangiocarcinoma. World J Gastroenterol 2027; 33(1): 123490
|
| URL |
https://www.wjgnet.com/1007-9327/full/v33/i1/123490.htm |
| DOI |
https://doi.org/10.3748/wjg.123490 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
