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Articles Published Processes
3/16/2015 6:04:00 PM | Browse: 1011 | Download: 1237
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Received |
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2014-07-04 09:40 |
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Peer-Review Started |
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2014-07-04 15:03 |
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To Make the First Decision |
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2014-07-21 12:57 |
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Return for Revision |
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2014-07-25 13:54 |
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Revised |
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2014-08-09 19:46 |
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Second Decision |
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2014-11-11 10:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-11 10:23 |
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Articles in Press |
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2014-11-11 10:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-12-29 16:48 |
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Typeset the Manuscript |
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2015-03-02 09:57 |
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Publish the Manuscript Online |
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2015-03-16 18:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Han-Fei Huang, Zhong Zeng, Kun-Hua Wang, Hai-Yan Zhang, Shuai Wang, Wen-Xiang Zhou, Zhan-Bo Wang, Wang-Gang Xu and Jian Duan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81360079 |
| Yunnan Provincial Science and Technology Department and Kunming Medical University Collaborative Fund |
2013FB142 |
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| Corresponding Author |
Zhong Zeng, MD, Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming 650032, Yunnan Province, China. zzong@medmail.com.cn |
| Key Words |
Heme oxygenase-1; Ischemia reperfusion injury; Toll-like receptor; Myeloid differentiation factor 88; Liver |
| Core Tip |
Heme oxygenase (HO)-1, a rate-limiting enzyme in heme degradation, has been shown to provide cytoprotection in various tissue and organ injury models. There is evidence suggesting that augmented Toll-like receptor (TLR) reactivity contributes to the development of heightened systemic inflammation following severe liver injury. In this study, by inducing the expression of HO-1 in a rat liver ischemia/reperfusion injury model, we demonstrated that HO-1 suppresses activation of the TLR2/TLR4-triggered myeloid differentiation factor 88 dependent pathway and promotes expression of negative regulators of TLR signaling. |
| Publish Date |
2015-03-16 18:04 |
| Citation |
Huang HF, Zeng Z, Wang KH, Zhang HY, Wang S, Zhou WX, Wang ZB, Xu WG, Duan J. Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. World J Gastroenterol 2015; 21(10): 2937-2948 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i10/2937.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i10.2937 |
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