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Articles Published Processes
11/5/2026 2:51:04 AM | Browse: 3 | Download: 1
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Received |
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2026-05-22 06:42 |
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Peer-Review Started |
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2026-05-22 06:42 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-01 03:17 |
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Revised |
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2026-07-13 15:39 |
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Publication Fee Transferred |
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2026-07-30 04:55 |
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Second Decision by Editor |
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2026-09-14 03:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-15 09:27 |
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Articles in Press |
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2026-09-15 09:27 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-19 01:18 |
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Publish the Manuscript Online |
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2026-11-05 02:51 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Resveratrol suppresses ulcerative colitis and colitis-associated colorectal cancer via modulating the miR-31-5p/SATB2 axis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Li Wu, Xi Wang, Xin-Xin Du, Kai-Li Liu, Chun-Fang Wang, Jin-Chun Liu, Ji-Min Cao and Xiang-Li Cui |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81272695 |
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| Corresponding Author |
Xiang-Li Cui, Full Professor, PhD, MOE Key Laboratory of Cellular Physiology, and Department of Physiology, Shanxi Medical University, No. 56 Xinjian South Road, Yingze District, Taiyuan 030001, Shanxi Province, China. cuixiangli@163.com |
| Key Words |
MiR-31-5p; Special AT-rich sequence-binding protein 2; Ulcerative colitis; Colitis-associated cancer; Azoxymethane; Dextran sulphate sodium; Resveratrol |
| Core Tip |
By integrating the microRNA sequencing data of human colorectal cancer from The Cancer Genome Atlas and the transcriptomic data from a small human ulcerative colitis (UC) cohort, we provisionally identify that miR-31-5p promotes the colonic inflammation-to-cancer transition. MiR-31-5p exacerbates dextran sulfate sodium-induced colitis and its transition to colitis-associated colorectal cancer (CAC) by targeting special AT-rich sequence-binding protein 2. The miR-31-5p/special AT-rich sequence-binding protein 2 axis is found to modulate Toll-like receptor-4/nuclear factor-κB and apoptosis pathways, revealing a key molecular link in UC-to-CAC transition. Resveratrol, a small plant-derived compound, ameliorates bowel inflammation and inhibits UC progression to CAC via this axis in mice in vivo. The study provides mechanistic insights into the UC-to-CAC progression and highlights the therapeutic potential of resveratrol for the diseases. |
| Publish Date |
2026-11-05 02:51 |
| Citation |
Wu YL, Wang X, Du XX, Liu KL, Wang CF, Liu JC, Cao JM, Cui XL. Resveratrol suppresses ulcerative colitis and colitis-associated colorectal cancer via modulating the miR-31-5p/SATB2 axis. World J Gastrointest Oncol 2026; 18(11): 123558
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i11/123558.htm |
| DOI |
https://doi.org/10.4251/wjgo.123558 |
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