Publication Name	World Journal of Gastroenterology
Manuscript ID	12358
Country	India

Received	2014-07-04 08:43
Peer-Review Started	2014-07-04 17:09
To Make the First Decision	2014-08-06 17:16
Return for Revision	2014-08-14 11:56
Revised	2014-08-28 17:30
Second Decision	2014-12-25 09:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-01-08 17:12
Articles in Press	2015-01-08 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-02 21:14
Publish the Manuscript Online	2015-03-16 18:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases
Manuscript Source	Invited Manuscript
All Author List	Dipanjana Datta De and Susanta Roychoudhury
Funding Agency and Grant Number
Corresponding Author	Susanta Roychoudhury, Chief Scientist, Cancer Biology and Inflammatory Disease Division, Indian Institute of Chemical Biology, 4, Raja S.C Mullick Road, Kolkata 700032, India. susanta@iicb.res.in
Key Words	Helicobacter pylori; Gastric cancer; Duodenal ulcer; Cytokine; Acid secretion
Core Tip	Helicobacter pylori infection results in diverse clinical outcomes. While duodenal ulcer is characterized by hyperacidity, gastric cancer results in hypoacidity. Virulence factors of the bacteria and its own genetic heterogeneity variability does not explain the divergent spectrum of disease manifestation. In this review, we highlight the host genetic factors that are involved and elicited by the bacteria. We discuss the different association studies performed with respect to gastric cancer and duodenal ulcer and further delineate the signaling cue of these inflammatory response pathway gene products to the gastrin: somatostatin axis that is known to regulate acid secretion.
Publish Date	2015-03-16 18:04
Citation	Datta De D, Roychoudhury S. To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases. World J Gastroenterol 2015; 21(10): 2883-2895
URL	http://www.wjgnet.com/1007-9327/full/v21/i10/2883.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i10.2883

Full Article (PDF)	WJG-21-2883.pdf
Full Article (Word)	WJG-21-2883.doc
Manuscript File	12358-Review.doc
Answering Reviewers	12358-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12358-Conflict-of-interest statement.pdf
Copyright License Agreement	12358-Copyright assignment.pdf
Peer-review Report	12358-Peer review(s).pdf
Scientific Misconduct Check	12358-CrossCheck.jpg
Scientific Editor Work List	12358-Scientific editor work list.pdf