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8/26/2026 5:34:16 AM | Browse: 1 | Download: 0
Publication Name World Journal of Cardiology
Manuscript ID 123626
Country China
Received
2026-05-25 07:27
Peer-Review Started
2026-05-25 07:27
First Decision by Editorial Office Director
Return for Revision
2026-06-22 03:20
Revised
2026-07-06 01:41
Publication Fee Transferred
2026-07-27 03:35
Second Decision by Editor
2026-08-20 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-08-20 08:46
Articles in Press
2026-08-20 08:46
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-08-24 01:01
Publish the Manuscript Online
2026-08-26 05:34
ISSN 1949-8462 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Review
Article Title Assessing residual cardiovascular risk and vulnerable plaques via non-traditional lipids: From biomarkers to novel targets for precision therapy
Manuscript Source Unsolicited Manuscript
All Author List Zi-Yi Lu, Ya-Fei Li, Lei Bao, Xu-Tong Wang, Hui Wu, Yin-Fei Xu, Yi Wang and Yan Chen
ORCID
Author(s) ORCID Number
Yan Chen http://orcid.org/0000-0001-9584-8968
Funding Agency and Grant Number
Funding Agency Grant Number
National Science and Technology Major Project 2023ZD0503902
Corresponding Author Yan Chen, Department of Emergency and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, No. 1 Lijiang Road, High-tech Zone, Suzhou 215000, Jiangsu Province, China. chenyandoc@njmu.edu.cn
Key Words Non-traditional lipid parameters; Vulnerable plaques; Residual cardiovascular risk; Atherosclerotic cardiovascular disease; Precision medicine; Lipoproteins
Core Tip Traditional lipids may underestimate residual cardiovascular risk and do not fully identify biologically vulnerable plaques. This review critically evaluates lipoprotein(a), low-density lipoprotein particle number, small dense low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, apolipoproteins E and A1, remnant cholesterol, and polyunsaturated fatty acids. It distinguishes guideline-endorsed measures from investigational biomarkers, summarizes clinically relevant thresholds and therapeutic evidence, and highlights assay standardization, unit conversion, and reference-interval limitations. Integration with plaque imaging and artificial intelligence may improve individualized risk stratification and precision prevention.
Publish Date 2026-08-26 05:34
Citation

Lu ZY, Li YF, Bao L, Wang XT, Wu H, Xu YF, Wang Y, Chen Y. Assessing residual cardiovascular risk and vulnerable plaques via non-traditional lipids: From biomarkers to novel targets for precision therapy. World J Cardiol 2026; 18(8): 123626

URL https://www.wjgnet.com/1949-8462/full/v18/i8/123626.htm
DOI https://doi.org/10.4330/wjc.123626
Full Article (PDF) WJC-18-123626-with-cover.pdf
Manuscript File 123626_Auto_Edited_050450.docx
Answering Reviewers 123626-answering-reviewers.pdf
Audio Core Tip 123626-audio.m4a
Conflict-of-Interest Disclosure Form 123626-conflict-of-interest-statement.pdf
Copyright License Agreement 123626-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 123626-non-native-speakers.pdf
Peer-review Report 123626-peer-reviews.pdf
Scientific Misconduct Check 123626-scientific-misconduct-check.png
CrossCheck Report 123626-crosscheck-report.pdf