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Articles Published Processes
8/26/2026 5:34:15 AM | Browse: 0 | Download: 0
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Received |
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2026-05-27 06:15 |
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Peer-Review Started |
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2026-05-27 06:15 |
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First Decision by Editorial Office Director |
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2026-06-09 02:13 |
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Return for Revision |
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2026-06-09 02:13 |
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Revised |
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2026-06-19 08:13 |
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Publication Fee Transferred |
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2026-07-29 02:01 |
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Second Decision by Editor |
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2026-08-14 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-14 09:38 |
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Articles in Press |
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2026-08-14 09:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-18 06:54 |
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Publish the Manuscript Online |
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2026-08-26 05:34 |
| ISSN |
1949-8462 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of 5-methoxytryptophan on cardiac structure and functions in a rat model of diabetic cardiomyopathy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Susetyo Atmojo, Bambang Budi Siswanto, Nurjati Chairani Siregar, Aria Kekalih, Fadlina Chany Saputri, Budi Susetyo Pikir, Deni Noviana, Apridya Nurhafizah, Riska Ferdian, Wilbert Huang and Puspita Eka Wuyung |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Susetyo Atmojo, Consultant, Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central, Jakarta 10430, Indonesia. susetyoatmojo30@gmail.com |
| Key Words |
Diabetic cardiomyopathy; 5-Methoxytryptophan; Cardiac remodeling; Echocardiography; N-terminal pro-B-type natriuretic peptide; Experimental model |
| Core Tip |
Diabetic cardiomyopathy (DCM) is characterized by progressive myocardial remodeling and a lack of therapies that specifically target the underlying inflammatory and fibrotic processes. This study evaluated the effects of 5-methoxytryptophan (5-MTP) in a rat model of DCM. Treatment with 5-MTP significantly reduced N-terminal pro-B-type natriuretic peptide levels and attenuated early structural remodeling but did not improve systolic or diastolic cardiac function. These findings suggest that 5-MTP may influence early myocardial remodeling; however, additional studies are needed to determine whether optimized dosing, longer treatment durations, or other treatment strategies can produce sustained structural and functional benefits. |
| Publish Date |
2026-08-26 05:34 |
| Citation |
Atmojo S, Siswanto BB, Siregar NC, Kekalih A, Saputri FC, Pikir BS, Noviana D, Nurhafizah A, Ferdian R, Huang W, Wuyung PE. Effects of 5-methoxytryptophan on cardiac structure and functions in a rat model of diabetic cardiomyopathy. World J Cardiol 2026; 18(8): 123639
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| URL |
https://www.wjgnet.com/1949-8462/full/v18/i8/123639.htm |
| DOI |
https://doi.org/10.4330/wjc.123639 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
