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Articles Published Processes
10/9/2026 4:02:20 AM | Browse: 8 | Download: 74
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Received |
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2026-05-25 07:38 |
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Peer-Review Started |
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2026-05-25 07:38 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-02 06:44 |
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Revised |
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2026-07-10 15:55 |
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Publication Fee Transferred |
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2026-07-20 15:34 |
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Second Decision by Editor |
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2026-07-24 03:17 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-28 12:21 |
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Articles in Press |
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2026-07-28 12:21 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-31 06:41 |
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Publish the Manuscript Online |
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2026-10-09 04:02 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Shortened eutectic mixture of lidocaine and prilocaine plus skin cooling for pediatric vaccination pain: A randomized non-inferiority trial
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Paveewan Jiravisitkul, Manunya Tandhansakul, Chanikarn Thongkam and Saraiorn Thonginnetra |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chulabhorn Royal Academy through the Research Excellence Group Funding Programmed of Chulabhorn Hospital, Chulabhorn Royal Academy |
544/2568 |
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| Corresponding Author |
Paveewan Jiravisitkul, Principal Investigator, Department of Pediatrics, Chulabhorn Hospital, Chulabhorn Royal Academy, 906 Kamphaeng Phet 6 Road, Talat Bang Khen Subdistrict, Lak Si, Bangkok 10210, Thailand. paveewan.jir@cra.ac.th |
| Key Words |
Pediatric vaccination; Procedural pain; Lidocaine-prilocaine; Skin cooling; Wong-Baker FACES Pain Rating Scale; Non-inferiority trial |
| Core Tip |
In this single-center, open-label, randomized non-inferiority trial conducted with 150 children aged 4-15 years who received a quadrivalent influenza vaccine, a 20-minute topical application of a eutectic mixture of lidocaine and prilocaine combined with 30 seconds of ice-pack skin cooling met the prespecified non-inferiority criterion for post-injection pain when compared with the standard 40-minute eutectic mixture of lidocaine and prilocaine regimen. The intervention reduced the preparation time by a median of 20 minutes. Exploratory analyses suggested fewer mild adverse events at 15 minutes, and caregiver satisfaction was high in both groups. This pragmatic, low-cost protocol is suitable for high-volume primary-care vaccination services. |
| Publish Date |
2026-10-09 04:02 |
| Citation |
Jiravisitkul P, Tandhansakul M, Thongkam C, Thonginnetra S. Shortened eutectic mixture of lidocaine and prilocaine plus skin cooling for pediatric vaccination pain: A randomized non-inferiority trial. World J Clin Pediatr 2026; 15(4): 123652
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| URL |
https://www.wjgnet.com/2219-2808/full/v15/i4/123652.htm |
| DOI |
https://doi.org/10.5409/wjcp.123652 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
