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Articles Published Processes
11/9/2026 4:15:47 AM | Browse: 1 | Download: 1
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Received |
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2026-05-26 06:05 |
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Peer-Review Started |
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2026-05-26 06:06 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-31 02:06 |
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Revised |
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2026-08-13 12:46 |
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Publication Fee Transferred |
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2026-09-08 02:46 |
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Second Decision by Editor |
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2026-10-08 07:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 09:04 |
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Articles in Press |
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2026-10-08 09:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-23 09:23 |
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Publish the Manuscript Online |
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2026-11-09 04:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Review |
| Article Title |
Small extracellular vesicles as liquid biopsy targets and precision therapeutics for metabolic dysfunction-associated steatotic liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling-Ling Ding, Han Liu, Yang Yu, Xue-Chao Liu, Shu-Qin Zhang, Hui Qian and Dong-Lin Hao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the High-Level Talent Scientific Research Start-up Funding of Jiangsu University |
5501280008 |
| Jiangsu Province Double Innovation Doctoral Talent Program |
JSSCBS20221179 |
| the China Postdoctoral Science Foundation |
2023M741425 |
| the Industry-University-Research Cooperation Project with Nanjing EVLiXiR |
8411283025 |
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| Corresponding Author |
Ling-Ling Ding, Wujin Institute of Molecular Diagnostics and Precision Cancer Medicine of Jiangsu University, Wujin Hospital Affiliated with Jiangsu University, No. 2 Yongning North Road, Changzhou 213002, Jiangsu Province, China. l.ding@ujs.edu.cn |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Small extracellular vesicles; Extracellular vesicles; Liquid biopsy; Biomarkers; Noninvasive tests; Drug delivery systems; Therapeutic strategies |
| Core Tip |
Metabolic dysfunction-associated steatotic liver disease (MASLD) lacks non-invasive biomarkers and targeted therapies. Small extracellular vesicles (sEVs) offer dual solutions: As diagnostic tools, sEV-derived miRNAs (e.g., miR-122), proteins (e.g., Kelch-like protein 41), and lipids enable accurate staging; as therapeutics, mesenchymal stem cell-derived sEVs reduce steatosis and fibrosis via autophagy and oxidative stress regulation, while engineered sEVs (e.g., cyclic arginine-glycine-aspartic acid-modified) enhance targeted delivery. sEVs thus shift from bystanders to key diagnostic and therapeutic players in MASLD. |
| Publish Date |
2026-11-09 04:15 |
| Citation |
Ding LL, Liu H, Yu Y, Liu XC, Zhang SQ, Qian H, Hao DL. Small extracellular vesicles as liquid biopsy targets and precision therapeutics for metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2027; 33(1): 123681
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| URL |
https://www.wjgnet.com/1007-9327/full/v33/i1/123681.htm |
| DOI |
https://doi.org/10.3748/wjg.123681 |
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