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8/7/2026 9:40:28 AM | Browse: 1 | Download: 0
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 123710
Country China
Received
2026-05-27 06:48
Peer-Review Started
2026-05-27 06:48
First Decision by Editorial Office Director
Return for Revision
2026-06-22 12:56
Revised
2026-07-04 06:30
Publication Fee Transferred
2026-07-24 14:36
Second Decision by Editor
2026-07-31 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-07-31 09:38
Articles in Press
2026-07-31 09:38
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-08-05 04:00
Publish the Manuscript Online
2026-08-07 09:40
ISSN 1948-5204 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Expression of tensin 4 in hepatocellular carcinoma and its role in epithelial-mesenchymal transformation
Manuscript Source Unsolicited Manuscript
All Author List Guo-Li Chen and Jian-Hua Liu
ORCID
Author(s) ORCID Number
Jian-Hua Liu http://orcid.org/0009-0002-9191-0028
Funding Agency and Grant Number
Corresponding Author Jian-Hua Liu, Chief Physician, Department of Hepatobiliary Surgery, The Second Hospital of Hebei Medical University, No. 215 West Heping Road, Shijiazhuang 050000, Hebei Province, China. 26300372@hebmu.edu.cn
Key Words Tensin4; C-terminal tensin-like; Slug; Hepatocellular carcinoma; HepG2 cells; PLC cells; Transforming growth factor-β1; Epithelial-mesenchymal transformation
Core Tip This study showed that tensin (TNS) 4 was highly expressed in hepatocellular carcinoma (HCC) tissues and correlated with poor prognosis. TNS4 may regulate Slug expression to mediate epithelial-mesenchymal transition via the transforming growth factor-β1/Smad signaling pathway, promoting proliferation, migration and invasion of HCC cells. TNS4 is expected to be a novel therapeutic target for HCC and merits further in-depth research.
Publish Date 2026-08-07 09:40
Citation

Chen GL, Liu JH. Expression of tensin 4 in hepatocellular carcinoma and its role in epithelial-mesenchymal transformation. World J Gastrointest Oncol 2026; 18(8): 123710

URL https://www.wjgnet.com/1948-5204/full/v18/i8/123710.htm
DOI https://doi.org/10.4251/wjgo.123710
Full Article (PDF) WJGO-18-123710-with-cover.pdf
Manuscript File 123710_Auto_Edited_070100.docx
Answering Reviewers 123710-answering-reviewers.pdf
Audio Core Tip 123710-audio.m4a
Biostatistics Review Certificate 123710-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 123710-conflict-of-interest-statement.pdf
Copyright License Agreement 123710-copyright-assignment.pdf
Institutional Review Board Approval Form or Document 123710-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 123710-non-native-speakers.pdf
Supplementary Material 123710-supplementary-material.pdf
Peer-review Report 123710-peer-reviews.pdf
Scientific Misconduct Check 123710-scientific-misconduct-check.png
Scientific Editor Work List 123710-scientific-editor-work-list.pdf
CrossCheck Report 123710-crosscheck-report.pdf