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Articles Published Processes
10/10/2026 9:09:51 AM | Browse: 0 | Download: 0
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Received |
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2026-06-02 10:40 |
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Peer-Review Started |
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2026-06-02 10:40 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-06-17 01:58 |
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Revised |
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2026-06-27 03:15 |
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Publication Fee Transferred |
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2026-06-30 02:22 |
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Second Decision by Editor |
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2026-07-10 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-10 06:08 |
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Articles in Press |
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2026-07-10 06:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-22 10:02 |
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Publish the Manuscript Online |
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2026-10-10 09:09 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Minireviews |
| Article Title |
Coordinated dysregulation of the hippocampus-amygdala-prefrontal cortex circuit in anxiety and depressive disorders: A narrative review
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xia Zhao, Wei Zhang, Dan Xu and Xing-An Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xing-An Liu, Department of Neurological Rehabilitation III, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Shenyang 110032, Liaoning Province, China. liuxing_an@126.com |
| Key Words |
Anxiety disorders; Depressive disorders; Hippocampus; Amygdala; Prefrontal cortex; Functional connectivity; Emotional regulation; Neural circuit |
| Core Tip |
This review highlights that anxiety and depressive disorders involve dysregulation of the hippocampus-amygdala-prefrontal cortex circuit, rather than isolated regional dysfunction. In anxiety, disruption of this circuit promotes hypervigilance to threats and the generalization of fear; in depression, it underlies negative memory bias and cognitive inflexibility. Comorbidity involves the reciprocal reinforcement of threat anticipation and negative memory. This circuit-based perspective links clinical phenomenology to neurobiology, guiding the development of biomarkers and interventions. |
| Publish Date |
2026-10-10 09:09 |
| Citation |
Zhao X, Zhang W, Xu D, Liu XA. Coordinated dysregulation of the hippocampus-amygdala-prefrontal cortex circuit in anxiety and depressive disorders: A narrative review. World J Psychiatry 2026; 16(10): 123719
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| URL |
https://www.wjgnet.com/2220-3206/full/v16/i10/123719.htm |
| DOI |
https://doi.org/10.5498/wjp.123719 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
