| Category |
Anesthesiology |
| Manuscript Type |
Basic Study |
| Article Title |
Preventive carnosine supplementation attenuates painful diabetic neuropathy via restoring mitochondrial function and suppressing inflammasome activation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhuo-Ying Yu, Jing Yang, Ye Jiang, Yong-Zheng Han, Min Wei, Jia-Yin Shou, Shi-Xiong Shen, Yan-Han Lyu, Xin-Sheng Li, Qian Chen, Xin-Ru Zhao, Guo-Gang Xing, Da-Qing Ma and Min Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82001329 and 82071411 |
| Beijing Municipal Natural Science Foundation |
No. 7204325 |
| Key Research Foundation of Peking University Third Hospital |
No. BYSYZD2019036 |
| Special Fund of the National Clinical Key Specialty Construction Program, China (2025) |
|
|
| Corresponding Author |
Min Li, Chief Physician, Deputy Director, MD, Professor, Department of Anesthesiology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China. liminanesth@bjmu.edu.cn |
| Key Words |
Painful diabetic neuropathy; Mitochondrial fission; Dynamin-related protein 1; NOD-like receptor pyrin domain-containing protein 3 inflammasome; Carnosine |
| Core Tip |
Painful diabetic neuropathy (PDN) is characterized by impaired mitochondrial function and reduced carnosine levels in the dorsal root ganglia. Untargeted metabolomic analysis identified carnosine deficiency as a metabolic alteration associated with PDN. Preventive carnosine supplementation alleviated behavioral, electrophysiological, and mitochondrial abnormalities in diabetic rats and was associated with reduced dynamin-related protein 1-related mitochondrial fission and NOD-like receptor pyrin domain-containing protein 3 inflammasome activation in dorsal root ganglia. These findings were further supported by complementary in vitro experiments, collectively supporting further preclinical and translational evaluation of carnosine as a potential early-intervention strategy for PDN. |
| Publish Date |
2026-10-12 06:27 |
| Citation |
Yu ZY, Yang J, Jiang Y, Han YZ, Wei M, Shou JY, Shen SX, Lyu YH, Li XS, Chen Q, Zhao XR, Xing GG, Ma DQ, Li M. Preventive carnosine supplementation attenuates painful diabetic neuropathy via restoring mitochondrial function and suppressing inflammasome activation. World J Diabetes 2026; 17(10): 123730
|
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i10/123730.htm |
| DOI |
https://doi.org/10.4239/wjd.123730 |
