BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/10/2026 9:09:51 AM | Browse: 1 | Download: 0
Publication Name World Journal of Psychiatry
Manuscript ID 123904
Country China
Received
2026-06-02 08:19
Peer-Review Started
2026-06-02 08:20
First Decision by Editorial Office Director
Return for Revision
2026-06-23 03:45
Revised
2026-07-07 01:27
Publication Fee Transferred
2026-08-11 08:17
Second Decision by Editor
2026-09-08 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-09-08 09:37
Articles in Press
2026-09-08 09:37
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-09-16 04:04
Publish the Manuscript Online
2026-10-10 09:09
ISSN 2220-3206 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychology
Manuscript Type Prospective Study
Article Title Feasibility of human-in-the-loop multimodal generative artificial intelligence chatbot for school-based adolescent mental health support
Manuscript Source Unsolicited Manuscript
All Author List Xi-Wang Fan, Ting-Yu Lin, Ming-Hao Wang, Li-Cheng Wu, Xin-Xi Chen, Jun-Yao Chen, Yi-Zhen Wu, Yu Zheng, Tang Li, Hao Du, Yao-Xuan Wang, Yu-Jie Wang, Jing-Wen Zhang, Li-Wei Huang, Tian-Ze Fan, Bing Liu, Jie Liu, Pei Sun, Hui Zhao, Guo-Lin Ma, Qiang Cheng and Shi-Jun Li
ORCID
Author(s) ORCID Number
Xi-Wang Fan http://orcid.org/0000-0003-4180-0496
Ting-Yu Lin http://orcid.org/0009-0003-2171-1565
Li-Cheng Wu http://orcid.org/0009-0009-2889-4935
Xin-Xi Chen http://orcid.org/0009-0003-4332-999X
Jun-Yao Chen http://orcid.org/0009-0009-5337-5002
Yi-Zhen Wu http://orcid.org/0009-0001-5007-0336
Yu Zheng http://orcid.org/0009-0003-5325-8080
Pei Sun http://orcid.org/0000-0002-5938-8180
Hui Zhao http://orcid.org/0009-0007-4100-0655
Shi-Jun Li http://orcid.org/0000-0001-8185-0549
Funding Agency and Grant Number
Funding Agency Grant Number
the Beijing Nova Programme Interdisciplinary Cooperation Project 20240484674
Capital’s Funds for Health Improvement and Research CFH2024-2-5024
the Tongji University Medicine-X Interdisciplinary Research Initiative 2025-0708-YB-02
Corresponding Author Shi-Jun Li, Department of Radiology, First Medical Center of Chinese PLA General Hospital, /, Beijing 100853, China. shijunli07@yeah.net
Key Words Generative artificial intelligence; Adolescent mental health; Chatbot; Feasibility study; Depression; Nonrandomized pilot study; Quasi-experimental study; Acceptance and commitment therapy; Safety monitoring; Human-in-the-loop
Core Tip This pilot study evaluated the supervised school-based implementation of Duoduo, an acceptance and commitment therapy-informed multimodal generative artificial intelligence chatbot developed for adolescents with elevated depressive symptoms. Most participants completed the 2-week intervention, engaged with the system for an average total duration of approximately 101 minutes, and reported a moderate working alliance. Risk-related conversation signals were referred for staff review through a predefined human-in-the-loop safety workflow. The findings primarily support the feasibility of implementation and provide guidance for future program planning. Clinical outcome findings were considered exploratory because participant allocation was pragmatic, baseline symptom severity differed between groups, multiple outcomes were evaluated, and the follow-up period was brief.
Publish Date 2026-10-10 09:09
Citation

Fan XW, Lin TY, Wang MH, Wu LC, Chen XX, Chen JY, Wu YZ, Zheng Y, Li T, Du H, Wang YX, Wang YJ, Zhang JW, Huang LW, Fan TZ, Liu B, Liu J, Sun P, Zhao H, Ma GL, Cheng Q, Li SJ. Feasibility of human-in-the-loop multimodal generative artificial intelligence chatbot for school-based adolescent mental health support. World J Psychiatry 2026; 16(10): 123904

URL https://www.wjgnet.com/2220-3206/full/v16/i10/123904.htm
DOI https://doi.org/10.5498/wjp.123904
Full Article (PDF) WJP-16-123904-with-cover.pdf
CONSORT 2010 Statement 123904-CONSORT-2010-statement.pdf
Manuscript File 123904_Auto_Edited_021535.docx
Answering Reviewers 123904-answering-reviewers.pdf
Audio Core Tip 123904-audio.mp3
Biostatistics Review Certificate 123904-biostatistics-statement.pdf
Clinical Trial Registration Statement 123904-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 123904-conflict-of-interest-statement.pdf
Copyright License Agreement 123904-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 123904-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 123904-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 123904-non-native-speakers.pdf
Supplementary Material 123904-supplementary-material.pdf
Peer-review Report 123904-peer-reviews.pdf
Scientific Misconduct Check 123904-scientific-misconduct-check.png
CrossCheck Report 123904-crosscheck-report.pdf