| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Prospective Study |
| Article Title |
Higher diversity of anti-diabetic therapy is associated with lower risk of major adverse kidney events in diabetes
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shu-Ping Zhang, Ting-Ting Huang, Qing-Lian Zeng, Wen-Jin Luo, Yun-Jie Xiong, Chuan Peng, Fei Lian, Qing-Feng Cheng, Zhi-Hong Wang, Wei Huang, Yong Xu, Qi-Fu Li, Shu-Min Yang, Xiang-Jun Chen, Jin-Bo Hu and Xi-Yue Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82671106 and No. 82501003 |
| National Science and Technology Major Project |
No. 2024ZD0523305 |
| Chongqing Outstanding Youth Science Fund Project |
No. CSTB2023NSCQ-JQX0028 |
| Science and Technology Research Project of Chongqing Education Commission |
No. KJQN202200403 and No. KJQN202500485 |
| he 74th Batch of General Funding from the China Postdoctoral Science Foundation |
No. 2023M740442 |
| 2023 State-Funded Postdoctoral Researcher Program of China Postdoctoral Science Foundation |
No. GZC20233341 |
|
| Corresponding Author |
Xi-Yue Li, MD, PhD, Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi St, Chongqing 400016, China. lixiyue@hospital.cqmu.edu.cn |
| Key Words |
Anti-diabetic therapy; Combination therapy; Major adverse kidney events; Target trial emulation; Type 2 diabetes mellitus |
| Core Tip |
Greater diversity of anti-diabetic therapy improves glycemic control, while its impact on kidney outcomes remains controversial. In two propensity-matched cohorts, combination therapy was associated with a 35%-76% lower major adverse kidney events risk vs monotherapy, independent of glycemic control and renoprotective medications. These findings support a potential association between greater diversity of anti-diabetic therapy and lower major adverse kidney events risk in patients with diabetes. |
| Publish Date |
2026-11-06 01:05 |
| Citation |
Zhang SP, Huang TT, Zeng QL, Luo WJ, Xiong YJ, Peng C, Lian F, Cheng QF, Wang ZH, Huang W, Xu Y, Li QF, Yang SM, Chen XJ, Hu JB, Li XY. Higher diversity of anti-diabetic therapy is associated with lower risk of major adverse kidney events in diabetes. World J Diabetes 2026; 17(11): 123922
|
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i11/123922.htm |
| DOI |
https://doi.org/10.4239/wjd.123922 |
