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Articles Published Processes
11/3/2026 4:47:30 AM | Browse: 2 | Download: 0
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Received |
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2026-06-03 07:34 |
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Peer-Review Started |
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2026-06-03 07:34 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-20 06:07 |
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Revised |
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2026-07-30 04:34 |
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Publication Fee Transferred |
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2026-08-11 03:06 |
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Second Decision by Editor |
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2026-09-07 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-08 09:38 |
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Articles in Press |
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2026-09-08 09:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-14 02:56 |
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Publish the Manuscript Online |
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2026-11-03 04:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Organoids as preclinical platforms for metabolic dysfunction-associated steatotic liver disease: Model construction, mechanistic dissection, and therapeutic translation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao-Yu Xue, Tian-Yi Ren, Qin Pan and Jian-Gao Fan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Noncommunicable Chronic Diseases-National Science and Technology Major Project |
023ZD0508700 |
| the National Natural Science Foundation of China |
82470600 |
| the Construction Project of the “Discipline Peak-Climbing Plan” of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine |
XKPF2024B401 |
| and the Postdoctoral Research Startup Fund of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine |
2025BS02 |
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| Corresponding Author |
Jian-Gao Fan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Organoid; Disease modeling; Mechanism |
| Core Tip |
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, yet targeted therapeutic options are limited. This review systematically summarizes liver organoids derived from human pluripotent stem cells, primary tissues, and immortalized cell lines in MASLD research, highlighting their distinct advantages in modeling MASLD pathogenesis, elucidating mechanisms, screening biomarkers, and validating therapeutics. It further discusses multi-tissue organoid systems, alongside current challenges and future directions to accelerate clinical translation and advance personalized medicine for MASLD. |
| Publish Date |
2026-11-03 04:47 |
| Citation |
Xue HY, Ren TY, Pan Q, Fan JG. Organoids as preclinical platforms for metabolic dysfunction-associated steatotic liver disease: Model construction, mechanistic dissection, and therapeutic translation. World J Gastroenterol 2026; 32(48): 123934
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i48/123934.htm |
| DOI |
https://doi.org/10.3748/wjg.123934 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
