9/22/2026 3:20:38 AM | Browse: 3 | Download: 1
| Publication Name | World Journal of Gastroenterology |
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| Manuscript ID | 123964 |
| Country | China |
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| ISSN | 1007-9327 (print) and 2219-2840 (online) |
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| Open Access | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright | ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||
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| Manuscript Type | Correspondence | ||||
| Article Title | Letter to the Editor: Rhubarb enema for acute pancreatitis - encouraging gut-immune signals with unconfirmed clinical benefit | ||||
| Manuscript Source | Unsolicited Manuscript | ||||
| All Author List | Sheng-Yu Huang, Xing-Wei Zhao, Qiu-Ting Li, Zi-Xu Ye and Chun-Xiang Zhang | ||||
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| Corresponding Author | Chun-Xiang Zhang, Dean, Professor, Department of Cardiology, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, SOUTHWEST MEDICAL UNIVERSITY, Department of Cardiology, The Affiliated Hospital, Southwest Medical University, No. 1, Section 1, Xianglin Road, Luzhou, Sichuan, 646000, China. zcxteam@163.com,Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, China. zcxteam@163.com,Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, Sichuan, 646000, China. zcxteam@163.com,Nucleic Acid Medicine of Luzhou Key Laboratory, Southwest Medical University, Luzhou, Sichuan, 646000, China. zcxteam@163.com, Luzhou 646000, Sichuan Province, China. zcxteam@163.com | ||||
| Key Words | Acute pancreatitis; Rhubarb enema; Gut-immune axis; Th17 cells; IL-17A; Intra-abdominal pressure; Randomized controlled trial; Patient-centered outcomes | ||||
| Core Tip | Rhubarb enema has shown promising intestinal-immune regulatory signals in acute pancreatitis, including a decrease in pro-inflammatory factors, a downregulation of the Th17/IL-17A pathway, an increase in IL-10, and an improvement in intra-abdominal pressure. However, recent randomized controlled studies have not shown a significant reduction in all-cause mortality at 28 days, and the actual event rate is lower than expected, with a relatively specific study population, which limits the certainty and generalizability of the conclusions. Rhubarb enema should currently be regarded as a potentially promising but unproven adjunctive intervention rather than a standard treatment that can immediately change clinical practice. Its clinical value still needs to be further verified in standardized procedures, clear stratified populations, and patient-centered hard endpoints. | ||||
| Publish Date | 2026-09-22 03:20 | ||||
| Citation |
Huang SY, Zhao XW, Li QT, Ye ZX, Zhang CX. Letter to the Editor: Rhubarb enema for acute pancreatitis - encouraging gut-immune signals with unconfirmed clinical benefit. World J Gastroenterol 2026; 32(42): 123964 |
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| URL | https://www.wjgnet.com/1007-9327/full/v32/i42/123964.htm | ||||
| DOI | https://doi.org/10.3748/wjg.123964 |
| Full Article (PDF) | WJG-32-123964-with-cover.pdf |
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| Manuscript File | 123964_Auto_Edited_031542.docx |
| Answering Reviewers | 123964-answering-reviewers.pdf |
| Audio Core Tip | 123964-audio.mp3 |
| Conflict-of-Interest Disclosure Form | 123964-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 123964-copyright-assignment.pdf |
| Non-Native Speakers of English Editing Certificate | 123964-non-native-speakers.pdf |
| Peer-review Report | 123964-peer-reviews.pdf |
| Scientific Misconduct Check | 123964-scientific-misconduct-check.png |
| CrossCheck Report | 123964-crosscheck-report.pdf |