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Articles Published Processes
11/11/2026 5:49:21 AM | Browse: 3 | Download: 0
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Received |
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2026-06-03 06:46 |
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Peer-Review Started |
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2026-06-03 06:46 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-16 03:19 |
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Revised |
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2026-07-29 01:30 |
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Publication Fee Transferred |
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2026-08-06 08:53 |
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Second Decision by Editor |
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2026-09-16 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-16 09:37 |
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Articles in Press |
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2026-09-16 09:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-27 00:35 |
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Publish the Manuscript Online |
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2026-11-11 05:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Autonomic nervous system as a key modulator in stress-related inflammatory bowel disease: Mechanisms and therapeutic implications
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Xin Hu, Xue-Ping Zhang, Cheng-Xiang Wang, Rui-Rong Yang, Li-Xin Ma, Suo-Wei Wu, Wen-Qi Jiang, Pu-Min Deng, Tao Zhang, Xiao-Lan Su and Wei Wei |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Pharmaceutical and Health Collaborative High-Quality R&D Project on Traditional Chinese Medicine |
zyygzl-2026-004 |
| National Pilot Project for Integrated Chinese and Western Medicine in the Management of Severe and Refractory Diseases: Ulcerative Colitis (Chronic Dysentery), and the Specialized Research Program for Self-Proposed Projects at Wangjing Hospital, China Academy of Chinese Medical Sciences |
WJYY-ZZXT-2025-35 |
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| Corresponding Author |
Wei Wei, Chief Physician, MD, Principal Investigator, Professor, Department of Gastroenterology, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6 South Middle Ring Road, Wangjing, Chaoyang District, Beijing 100102, China. sxxtyy@sina.com |
| Key Words |
Autonomic nervous system; Brain-gut axis; Stress; Inflammatory bowel disease; Mechanism; Therapy |
| Core Tip |
This review provides a novel perspective on stress-associated inflammatory bowel disease by highlighting autonomic nervous system dysregulation as a key link between psychological stress and intestinal inflammation. We discuss the dual roles of sympathetic and vagal pathways, disease-specific autonomic responses in ulcerative colitis and Crohn’s disease, and emerging autonomic nervous system-targeted therapies. Current controversies and future directions toward personalized neuromodulation are also addressed. |
| Publish Date |
2026-11-11 05:49 |
| Citation |
Hu XX, Zhang XP, Wang CX, Yang RR, Ma LX, Wu SW, Jiang WQ, Deng PM, Zhang T, Su XL, Wei W. Autonomic nervous system as a key modulator in stress-related inflammatory bowel disease: Mechanisms and therapeutic implications. World J Gastroenterol 2027; 33(2): 123982
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| URL |
https://www.wjgnet.com/1007-9327/full/v33/i2/123982.htm |
| DOI |
https://doi.org/10.3748/wjg.123982 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
