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Articles Published Processes
11/5/2026 2:51:01 AM | Browse: 3 | Download: 1
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Received |
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2026-06-05 06:41 |
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Peer-Review Started |
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2026-06-05 06:41 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-13 09:44 |
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Revised |
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2026-07-27 08:55 |
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Publication Fee Transferred |
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2026-08-14 12:20 |
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Second Decision by Editor |
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2026-09-10 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-10 09:21 |
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Articles in Press |
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2026-09-10 09:21 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-16 00:52 |
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Publish the Manuscript Online |
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2026-11-05 02:51 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Propensity score-based real-world study of immune checkpoint inhibitor combination therapy in microsatellite stable/proficient mismatch repair metastatic colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chang Zhang, Shi-Hao Wu, Lei Jin, Liang Lu, Ji Li and Shui Jin |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shui Jin, Department of Gastroenterology, The Fourth Affiliated Hospital of Anhui Medical University, No. 64 Chaohu North Road, Juchao District, Chaohu, Hefei 238000, Anhui Province, China. e-ch2009640010@fy.ahmu.edu.cn |
| Key Words |
Metastatic colorectal cancer; Microsatellite stable; Immune checkpoint inhibitors; Anti-angiogenic therapy; Inflammatory biomarkers |
| Core Tip |
Immune checkpoint inhibitors have limited efficacy in microsatellite stable/proficient mismatch repair metastatic colorectal cancer. This real-world study showed that immune checkpoint inhibitor-based combination therapy with chemotherapy and anti-angiogenic agents was associated with improved progression-free survival after propensity score adjustment. Liver metastasis and tumor sidedness showed exploratory prognostic and treatment-related signals, although subgroup findings require further validation. Post-treatment neutrophil‑to‑lymphocyte ratio and systemic immune‑inflammation index may provide additional risk stratification value. These findings offer clinically relevant evidence supporting further prospective evaluation of immune checkpoint inhibitor-based combination strategies in microsatellite stable/proficient mismatch repair metastatic colorectal cancer. |
| Publish Date |
2026-11-05 02:51 |
| Citation |
Zhang C, Wu SH, Jin L, Lu L, Li J, Jin S. Propensity score-based real-world study of immune checkpoint inhibitor combination therapy in microsatellite stable/proficient mismatch repair metastatic colorectal cancer. World J Gastrointest Oncol 2026; 18(11): 124022
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i11/124022.htm |
| DOI |
https://doi.org/10.4251/wjgo.124022 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
