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Articles Published Processes
11/5/2026 2:51:01 AM | Browse: 3 | Download: 1
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Received |
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2026-06-05 06:21 |
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Peer-Review Started |
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2026-06-05 06:21 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-06-22 07:22 |
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Revised |
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2026-06-30 21:30 |
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Publication Fee Transferred |
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2026-07-14 12:56 |
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Second Decision by Editor |
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2026-08-26 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-26 08:40 |
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Articles in Press |
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2026-08-26 08:40 |
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Edit the Manuscript by Language Editor |
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2026-09-01 19:34 |
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Typeset the Manuscript |
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2026-09-16 08:03 |
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Publish the Manuscript Online |
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2026-11-05 02:51 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
GINS complex couples DNA replication stress to therapeutic resistance in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao-Wen Yang, Xi Chen, Wen-Jie Wu, Liu Yang and Xing-Bao Fang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science Research Fund Project of Yunnan Provincial Department of Education |
2026Y0383 |
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| Corresponding Author |
Xing-Bao Fang, Chief, Chief Physician, Head, MD, Professor, Department of Hepatobiliary and Pancreatic Surgery, Qujing Central Hospital of Yunnan Province, No. 1 Yuanlin Road, Qujing 655000, Yunnan Province, China. fangxingbao@kmmu.edu.cn |
| Key Words |
GINS complex; DNA replication stress; CMG helicase; Cancer stemness; Therapeutic resistance; Hepatocellular carcinoma |
| Core Tip |
This review highlights the GINS complex, a core component of the CMG helicase, as a candidate molecular link between DNA replication stress adaptation, cancer stemness, epithelial-mesenchymal transition, and therapeutic resistance in hepatocellular carcinoma (HCC). Current evidence is strongest for GINS1, GINS2, and GINS4, whereas HCC-specific functional validation of GINS3 remains limited. The GINS-CMG axis should therefore be viewed as a hypothesis-generating biomarker and translational concept rather than an established therapeutic target. |
| Publish Date |
2026-11-05 02:51 |
| Citation |
Yang HW, Chen X, Wu WJ, Yang L, Fang XB. GINS complex couples DNA replication stress to therapeutic resistance in hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(11): 124074
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i11/124074.htm |
| DOI |
https://doi.org/10.4251/wjgo.124074 |
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