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Articles Published Processes
9/20/2026 4:00:01 AM | Browse: 4 | Download: 7
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Received |
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2026-06-08 01:03 |
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Peer-Review Started |
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2026-06-08 01:03 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-23 03:26 |
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Revised |
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2026-07-27 12:13 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-08-26 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-26 08:41 |
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Articles in Press |
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2026-08-26 08:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-31 06:47 |
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Publish the Manuscript Online |
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2026-09-20 04:00 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Minireviews |
| Article Title |
Metagenomic next-generation sequencing in the diagnosis of viral encephalitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Umut Devrim Binay, Faruk Karakeçili, Orçun Barkay and Betül Sümer |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Umut Devrim Binay, Associate Professor, MD, Department of Infectious Diseases and Clinical Microbiology, Erzincan Binali Yildirim University, Faculty of Medicine, Hacı Ali Akın Street, Basbaglar District, Erzincan 24000, Türkiye. umut.binay@erzincan.edu.tr |
| Key Words |
Viral encephalitis; Metagenomic next-generation sequencing; Neuroinfection; Viral diagnostics; Central nervous system infections |
| Core Tip |
Metagenomic next-generation sequencing broadens the diagnostic search in viral encephalitis by detecting pathogen nucleic acids without a predefined target. Its highest value is in severe, unexplained, atypical, or immunocompromised cases after urgent targeted testing and empirical treatment have started. It performs less reliably when pathogen burden is low, infection is tissue-restricted, or diagnosis depends mainly on serology. Results therefore require contamination controls, clinical correlation, and confirmatory testing. Metagenomic next-generation sequencing complements rather than replaces polymerase chain reaction, serology, and conventional microbiology. |
| Publish Date |
2026-09-20 04:00 |
| Citation |
Binay UD, Karakeçili F, Barkay O, Sümer B. Metagenomic next-generation sequencing in the diagnosis of viral encephalitis. World J Virol 2026; 15(3): 124097
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| URL |
https://www.wjgnet.com/2220-3249/full/v15/i3/124097.htm |
| DOI |
https://doi.org/10.5501/wjv.124097 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
