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Articles Published Processes
11/5/2026 2:51:00 AM | Browse: 3 | Download: 1
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Received |
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2026-06-08 06:08 |
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Peer-Review Started |
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2026-06-08 06:09 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-06 06:56 |
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Revised |
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2026-07-14 12:12 |
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Publication Fee Transferred |
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2026-07-31 14:29 |
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Second Decision by Editor |
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2026-08-27 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-28 09:29 |
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Articles in Press |
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2026-08-28 09:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-10-18 14:18 |
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Publish the Manuscript Online |
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2026-11-05 02:51 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qian-Cheng Du, Yu Bai, De-Hua Zhou, Hua Yu and Hui Nian |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hui Nian, MD, Department of Thoracic Surgery, Shanghai Xuhui Central Hospital, No. 366 Longchuan North Road, Xuhui District, Shanghai 200031, China. hnian14@fudan.edu.cn |
| Key Words |
Fatty acid desaturase 1; Esophageal cancer; Ferroptosis; Phospholipid metabolism; Lipid raft |
| Core Tip |
Esophageal cancer patients have a poor prognosis with unclear immunometabolic mechanisms. Fatty acid desaturase 1 (FADS1), a key lipid metabolism enzyme, is linked to multiple cancers, but its role in esophageal cancer immunity is unknown. In this study, FADS1, which is overexpressed in tumor-infiltrating M1 macrophages, was identified as a causal factor for esophageal cancer. Mechanistically, FADS1 accumulates 1-palmitoyl-2-stearoyl-glycerophosphocholine, promotes lipid raft assembly, and triggers ferroptosis in M1 macrophages, impairing their antitumor function. Inhibiting FADS1 expression suppressed ferroptosis and restored M1 macrophage activity. The FADS1 inhibitor BRD-K95779464 was identified by artificial intelligence screening. This work reveals a novel FADS1-mediated immunometabolic pathway in esophageal cancer. |
| Publish Date |
2026-11-05 02:51 |
| Citation |
Du QC, Bai Y, Zhou DH, Yu H, Nian H. Fatty acid desaturase 1 drives esophageal cancer via M1 macrophage ferroptosis and lipid metabolism remodeling. World J Gastrointest Oncol 2026; 18(11): 124110
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i11/124110.htm |
| DOI |
https://doi.org/10.4251/wjgo.124110 |
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