| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Diabetes as a pan-cancer risk factor: Triangulated evidence from global burden, longitudinal cohorts, and Mendelian randomization
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ye Lu, Mao-Sheng Chai, Qing-Ying Lan, Qing-Mo Yang, Fu-Rong Yang, Ting-Ning Xiao, Xiao-Wen Kong, Pei-Ru Zhou and Hong Hua |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Key Research and Development Program of China |
No. 2023YFC3605603 |
| the Program of the New Clinical Techniques of Peking University School and Hospital of Stomatology |
No. PKUSSNCT-24A10 |
| the Beijing High-Level Innovative and Entrepreneurship Talent Support Program, Young Backbone Talent Projects |
No. G202531217 |
|
| Corresponding Author |
Hong Hua, Chief Physician, MD, PhD, Professor, Department of Oral Medicine, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, No. 22 Zhongguancun South Street, Haidian District, Beijing 100081, China. honghua1968@aliyun.com |
| Key Words |
Diabetes; Hyperglycemia; Pan-cancer; Cancer burden; Cancer-specific mortality; Risk stratification |
| Core Tip |
Using multiple independent datasets and Mendelian randomization, this study links diabetes to a rising pan-cancer burden, higher cancer prevalence and poorer survival. Longer diabetes duration and higher insulin-resistance markers showed dose-response associations with cancer prevalence, identifying diabetes-related indicators as quantifiable markers of cancer risk. These findings support diabetes-informed cancer risk stratification, targeted prevention and longitudinal surveillance in high-risk populations. |
| Publish Date |
2026-11-06 01:05 |
| Citation |
Lu Y, Chai MS, Lan QY, Yang QM, Yang FR, Xiao TN, Kong XW, Zhou PR, Hua H. Diabetes as a pan-cancer risk factor: Triangulated evidence from global burden, longitudinal cohorts, and Mendelian randomization. World J Diabetes 2026; 17(11): 124123
|
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i11/124123.htm |
| DOI |
https://doi.org/10.4239/wjd.124123 |
