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Articles Published Processes
9/3/2026 2:08:39 AM | Browse: 0 | Download: 0
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Received |
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2026-06-09 02:38 |
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Peer-Review Started |
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2026-06-09 02:38 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-07 06:39 |
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Revised |
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2026-07-19 16:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-08-10 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-10 10:44 |
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Articles in Press |
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2026-08-10 10:44 |
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Edit the Manuscript by Language Editor |
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2026-08-17 01:56 |
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Typeset the Manuscript |
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2026-08-27 00:22 |
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Publish the Manuscript Online |
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2026-09-03 02:08 |
| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Perspectives on the bioenergetic dysregulation in insulin-resistant patients comorbid with cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dina Johar, Khaled Mahmoud and Samy Zaky |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dina Johar, PhD, Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Ain Shams University, Asma Fahme Street, Heliopolis, Cairo 11757, Egypt. dinajohar@gu.edu.eg |
| Key Words |
Insulin resistance; Platelets; Cancer; Dipeptidyl peptidase 4; Mitochondrial bioenergetics |
| Core Tip |
This perspective proposes that insulin-resistant cancer patients exhibit reduced platelet mitochondrial bioenergetics compared to non-insulin-resistant cancer patients or healthy controls, and that platelet mitochondrial profiling may serve as an early marker of mitochondrial dysfunction in this population. It further hypothesizes that dipeptidyl peptidase 4 inhibition may ameliorate insulin resistance in cancer patients and proposes a cell culture model to test this hypothesis. The article’s clinical relevance lies in potentially identifying non-invasive biomarkers for metabolic dysfunction in cancer patients and exploring dipeptidyl peptidase 4 inhibitors as therapeutics. Strengths include the integration of cancer biology, metabolic syndrome pathophysiology, and mitochondrial bioenergetics, and the proposal of testable frameworks. |
| Publish Date |
2026-09-03 02:08 |
| Citation |
Johar D, Mahmoud K, Zaky S. Perspectives on the bioenergetic dysregulation in insulin-resistant patients comorbid with cancer. World J Transl Med 2026; 12(3): 124147
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| URL |
https://www.wjgnet.com/2220-6132/full/v12/i3/124147.htm |
| DOI |
https://doi.org/10.5528/wjtm.124147 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
