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Articles Published Processes
12/10/2015 10:35:00 AM | Browse: 1051 | Download: 1312
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Received |
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2014-07-07 17:20 |
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Peer-Review Started |
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2014-07-08 15:43 |
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To Make the First Decision |
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2014-09-15 16:13 |
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Return for Revision |
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2014-09-22 08:19 |
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Revised |
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2014-10-23 14:31 |
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Second Decision |
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2014-11-21 09:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-12-16 10:13 |
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Articles in Press |
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2014-12-16 10:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-12-31 01:42 |
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Typeset the Manuscript |
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2015-03-09 19:21 |
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Publish the Manuscript Online |
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2015-03-19 16:57 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Urotensin II alteration and effects on cytokines in early acute liver failure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Liang-Ming Liu, Liang Zhao, Dong-Yu Liang, Fang-Ping Yu, Chang-Gen Ye, Wen-Juan Tu and Tong Zhu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81070357 |
| National Natural Science Foundation of China |
30660066 |
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| Corresponding Author |
Liang-Ming Liu, MD, PhD, Department of Infection, Songjiang Hospital Affiliated to the First People’s Hospital, Shanghai Jiaotong University, 800 Dongchuan RD, Minhang District, Shanghai 201600, China. liuliangming@hotmail.com |
| Key Words |
Acute hepatic failure; Urotensin II; Urantide; Tumor necrosis factor α; Interleukin-1β; Mouse |
| Core Tip |
In this study, we found that increased urotensin II (UII) was an earlier event than tumor necrosis factor α (TNF-α) and interleukin (IL)-1β following lipopolysaccharide (LPS)/D-galactosamine (D-GalN) challenge, and pretreatment with urantide, an inhibitor of the UII receptor, blocked TNF-α and IL-1β increases following downregulation of UII in liver and blood at different time points after challenge. Therefore, UII may play a pivotal role in the pathogenesis and priming of acute liver failure by triggering the inflammatory cascade, and initiating and driving the early release of TNF-α and IL-1β in LPS/D-GalN-challenged mice. |
| Publish Date |
2015-03-19 16:57 |
| Citation |
Liu LM, Zhao L, Liang DY, Yu FP, Ye CG, Tu WJ, Zhu T. Effects of urotensin-Ⅱ on cytokines in early acute liver failure in mice. World J Gastroenterol 2015; 21(11): 3239-3244 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i11/3239.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i11.3239 |
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