Publication Name	World Journal of Gastroenterology
Manuscript ID	12417
Country	China

Received	2014-07-07 17:20
Peer-Review Started	2014-07-08 15:43
First Decision by Editorial Office Director
Return for Revision	2014-09-22 08:19
Revised	2014-10-23 14:31
Publication Fee Transferred
Second Decision by Editor	2014-11-21 09:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-12-16 10:13
Articles in Press	2014-12-16 10:41
Edit the Manuscript by Language Editor	2014-12-31 01:42
Typeset the Manuscript	2015-03-09 19:21
Publish the Manuscript Online	2015-03-19 16:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Urotensin II alteration and effects on cytokines in early acute liver failure
Manuscript Source	Unsolicited Manuscript
All Author List	Liang-Ming Liu, Liang Zhao, Dong-Yu Liang, Fang-Ping Yu, Chang-Gen Ye, Wen-Juan Tu and Tong Zhu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81070357 National Natural Science Foundation of China 30660066
Corresponding Author	Liang-Ming Liu, MD, PhD, Department of Infection, Songjiang Hospital Affiliated to the First People’s Hospital, Shanghai Jiaotong University, 800 Dongchuan RD, Minhang District, Shanghai 201600, China. liuliangming@hotmail.com
Key Words	Acute hepatic failure; Urotensin II; Urantide; Tumor necrosis factor α; Interleukin-1β; Mouse
Core Tip	In this study, we found that increased urotensin II (UII) was an earlier event than tumor necrosis factor α (TNF-α) and interleukin (IL)-1β following lipopolysaccharide (LPS)/D-galactosamine (D-GalN) challenge, and pretreatment with urantide, an inhibitor of the UII receptor, blocked TNF-α and IL-1β increases following downregulation of UII in liver and blood at different time points after challenge. Therefore, UII may play a pivotal role in the pathogenesis and priming of acute liver failure by triggering the inflammatory cascade, and initiating and driving the early release of TNF-α and IL-1β in LPS/D-GalN-challenged mice.
Publish Date	2015-03-19 16:57
Citation	Liu LM, Zhao L, Liang DY, Yu FP, Ye CG, Tu WJ, Zhu T. Effects of urotensin-Ⅱ on cytokines in early acute liver failure in mice. World J Gastroenterol 2015; 21(11): 3239-3244
URL	http://www.wjgnet.com/1007-9327/full/v21/i11/3239.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i11.3239

Full Article (PDF)	WJG-21-3239.pdf
Full Article (Word)	WJG-21-3239.doc
Manuscript File	12417-Review.doc
Answering Reviewers	12417-Answering reviewers.pdf
Copyright License Agreement	12417-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12417-Language certificate.PDF
Peer-review Report	12417-Peer review(s).pdf
Scientific Misconduct Check	12417-CrossCheck.jpg
Scientific Editor Work List	12417-Scientific editor work list.pdf