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Articles Published Processes
9/7/2026 5:29:05 AM | Browse: 3 | Download: 0
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Received |
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2026-06-09 03:21 |
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Peer-Review Started |
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2026-06-09 03:21 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-06-25 06:08 |
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Revised |
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2026-07-01 08:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-07-14 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-14 07:59 |
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Articles in Press |
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2026-07-14 07:59 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-03 00:18 |
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Publish the Manuscript Online |
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2026-09-07 05:29 |
| ISSN |
2220-3176 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Minireviews |
| Article Title |
Post-acute COVID-19 gastrointestinal sequelae: Mechanisms of persistent dysbiosis, intestinal barrier dysfunction, and emerging long-COVID phenotypes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ahmed Salman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ahmed Salman, FRACP, FRCP, MRCP, Internal Medicine, Kasr Alainy School of Medicine, 1 Al-Saray Street, Al-Manial, Cairo 3178, Al Qāhirah, Egypt. awea844@gmail.com |
| Key Words |
Long COVID; Gut dysbiosis; Intestinal barrier dysfunction; Short-chain fatty acids; Microbiota-targeted therapy |
| Core Tip |
Long-coronavirus disease gastrointestinal manifestations affect 10%-30% of survivors, but remain overlooked. Persistent dysbiosis-the loss of beneficial bacteria and pathogenic enrichment-drives symptoms through barrier dysfunction, immune dysregulation, and endotoxemia. Dysbiosis has been implicated as a potential contributor to short-chain fatty acid depletion and impaired tryptophan metabolism; however, current human evidence is largely observational, and causality remains unproven. Clinical biomarkers (zonulin, I-FABP, and dysbiotic signatures) enable patient stratification. Microbiota-targeted interventions (probiotics, synbiotics, fecal microbiota transplantation, and postbiotics) offer rational therapeutic approaches. This review establishes dysbiosis as a central therapeutic target and provides an evidence-based framework for its clinical management. |
| Publish Date |
2026-09-07 05:29 |
| Citation |
Salman A. Post-acute COVID-19 gastrointestinal sequelae: Mechanisms of persistent dysbiosis, intestinal barrier dysfunction, and emerging long-COVID phenotypes. World J Clin Infect Dis 2026; 15(1): 124175
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| URL |
https://www.wjgnet.com/2220-3176/full/v15/i1/124175.htm |
| DOI |
https://doi.org/10.5495/wjcid.124175 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
