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Articles Published Processes
10/27/2026 6:30:56 AM | Browse: 4 | Download: 2
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Received |
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2026-06-09 05:50 |
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Peer-Review Started |
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2026-06-09 05:50 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-01 01:12 |
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Revised |
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2026-07-14 04:33 |
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Publication Fee Transferred |
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2026-07-21 15:19 |
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Second Decision by Editor |
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2026-07-27 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-27 09:51 |
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Articles in Press |
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2026-07-27 09:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-14 00:37 |
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Publish the Manuscript Online |
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2026-10-27 06:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Integrating metabolomics, clinical factors, and genetic risk for colorectal cancer risk prediction: Model development and internal-external cross-validation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Liang-Tang Zeng, Jun-Nan Hu, Ming-Hui Pang, Qin-Xing Cao, Neng-Yi Hou and Feng Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Special Project for Clinical Research in Health Industry of Shanghai Municipal Health Commission |
No. 202540026 |
| Cultivation Grant for Clinical and Basic Integration Research of Shanghai Tenth People’s Hospital |
No. SYYYRH2025006 |
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| Corresponding Author |
Feng Liu, Chief Physician, Full Professor, Digestive Endoscopy Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, No. 301 Yanchang Road, Shanghai 200072, China. 1905041@tongji.edu.cn |
| Key Words |
Plasma metabolomics; Colorectal cancer; Risk prediction; Risk stratification; Polygenic risk score |
| Core Tip |
Using data from 468095 UK Biobank participants, we evaluated 325 nuclear magnetic resonance-based plasma metabolic markers and developed a seven-feature metabolomic risk score for incident colorectal cancer. The score stratified long-term risk and modestly improved prediction when added to an adapted QCancer clinical model and a polygenic risk score. Internal-external cross-validation across 10 geographical clusters supported consistency and geographical transportability within the UK Biobank. These findings suggest that metabolomics may complement, rather than replace, established clinical and genetic risk assessment. Independent external validation and cost-effectiveness evaluation are required before clinical implementation. |
| Publish Date |
2026-10-27 06:30 |
| Citation |
Zeng LT, Hu JN, Pang MH, Cao QX, Hou NY, Liu F. Integrating metabolomics, clinical factors, and genetic risk for colorectal cancer risk prediction: Model development and internal-external cross-validation. World J Gastroenterol 2026; 32(47): 124207
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i47/124207.htm |
| DOI |
https://doi.org/10.3748/wjg.124207 |
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