BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/9/2026 8:15:10 AM | Browse: 2 | Download: 3
 |
Received |
|
2026-06-10 02:49 |
|
Peer-Review Started |
|
2026-06-10 02:49 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2026-07-01 06:58 |
|
Revised |
|
2026-07-12 09:47 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-08-10 02:45 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-08-10 10:45 |
|
Articles in Press |
|
2026-08-10 10:45 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-09-07 00:40 |
|
Publish the Manuscript Online |
|
2026-10-09 08:15 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Differentiation-inducing therapy: A potential therapeutic strategy that targets liver cancer stem cells
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Hao Luo, Meng-Ting Yao, Min-Jie Yu and Tao Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81502696 |
| Program of General Hospital of Western Theater Command |
2021-XZYG-C33, 2024-YGJC-A12 |
| Science & Technology Department of Sichuan Provence International Cooperation Program |
2019YFH0056 |
|
| Corresponding Author |
Tao Wang, MD, Department of General Surgery, General Hospital of Western Theater Command, No. 270 Rongdu Avenue, Chengdu 610083, Sichuan Province, China. wangtao301020@sina.com |
| Key Words |
Differentiation-inducing therapy; Liver cancer; Liver stem/progenitor cells; Liver cancer stem cells; Malignant transformation |
| Core Tip |
Differentiation-inducing therapy may be a potential strategy for hepatocellular carcinoma (HCC), as it can target both the arrested differentiation of liver stem/progenitor cells and the dedifferentiation of mature hepatocytes. We systematically retrieved and analyzed recent relevant research on liver cancer stem cells (LCSCs) origin and differentiation therapy, and we summarized how differentiation-inducing therapy plays therapeutic role based on the theory of LCSCs. In addition, we explored the potential molecules and agents with differentiation-inducing therapeutic effect, and assessed translational prospects and clinical applicability of these candidate agents for future HCC treatment. |
| Publish Date |
2026-10-09 08:15 |
| Citation |
Luo H, Yao MT, Yu MJ, Wang T. Differentiation-inducing therapy: A potential therapeutic strategy that targets liver cancer stem cells. World J Gastrointest Oncol 2026; 18(10): 124235
|
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i10/124235.htm |
| DOI |
https://doi.org/10.4251/wjgo.124235 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
