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10/29/2026 7:19:21 AM | Browse: 2 | Download: 0
Publication Name World Journal of Psychiatry
Manuscript ID 124324
Country China
Received
2026-06-12 08:49
Peer-Review Started
2026-06-12 08:50
First Decision by Editorial Office Director
Return for Revision
2026-07-27 02:27
Revised
2026-08-09 15:42
Publication Fee Transferred
2026-08-26 01:40
Second Decision by Editor
2026-09-15 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-09-15 09:31
Articles in Press
2026-09-15 09:31
Edit the Manuscript by Language Editor
2026-09-16 04:32
Typeset the Manuscript
2026-10-10 07:50
Publish the Manuscript Online
2026-10-29 07:19
ISSN 2220-3206 (online)
Open Access Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychiatry
Manuscript Type Minireviews
Article Title Interoceptive aberrations in major depressive disorder: Neural mechanisms, clinical correlates, and targeted interventions
Manuscript Source Unsolicited Manuscript
All Author List Hui Deng, Ya-Qing Wang, Yi-Fan Sun, Hong-Liang Zhou and Zhen-He Zhou
ORCID
Author(s) ORCID Number
Hui Deng http://orcid.org/0009-0001-8541-0871
Ya-Qing Wang http://orcid.org/0009-0000-0595-2594
Yi-Fan Sun http://orcid.org/0009-0006-9554-401X
Hong-Liang Zhou http://orcid.org/0000-0002-6496-3346
Zhen-He Zhou http://orcid.org/0000-0002-1334-8335
Funding Agency and Grant Number
Funding Agency Grant Number
Wuxi Municipal Health Commission Major Project Z202107
Wuxi Taihu Talent Project WXTTP 2021
Corresponding Author Zhen-He Zhou, Chief Physician, MD, PhD, Professor, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, No. 156 Qianrong Road, Wuxi 214151, Jiangsu Province, China. zhouzh@jiangnan.edu.cn
Key Words Interoception; Major depressive disorder; Active inference; Brain-body regulation; Somatic symptoms; Neural networks; Therapeutic interventions
Core Tip This narrative review reframes the apparently inconsistent interoceptive findings in major depressive disorder (MDD) as a multidimensional pattern, with part of the apparent heterogeneity across studies related to measurement choice and illness stage. By comparing major assessment approaches and integrating behavioral, neurobiological, and clinical evidence, we identify where findings across interoceptive domains converge and diverge, with active inference serving as a heuristic perspective for interpreting selected links across levels of analysis. This synthesis points toward future stage-sensitive, multimodal assessment and more mechanism-informed intervention research in MDD.
Publish Date 2026-10-29 07:19
Citation

Deng H, Wang YQ, Sun YF, Zhou HL, Zhou ZH. Interoceptive aberrations in major depressive disorder: Neural mechanisms, clinical correlates, and targeted interventions. World J Psychiatry 2026; 16(11): 124324

URL https://www.wjgnet.com/2220-3206/full/v16/i11/124324.htm
DOI https://doi.org/10.5498/wjp.124324
Full Article (PDF) WJP-16-124324-with-cover.pdf
Manuscript File 124324_Auto_Edited_011648.docx
Answering Reviewers 124324-answering-reviewers.pdf
Audio Core Tip 124324-audio.mp3
Conflict-of-Interest Disclosure Form 124324-conflict-of-interest-statement.pdf
Copyright License Agreement 124324-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 124324-non-native-speakers.pdf
Supplementary Material 124324-supplementary-material.pdf
Peer-review Report 124324-peer-reviews.pdf
Scientific Misconduct Check 124324-scientific-misconduct-check.png
CrossCheck Report 124324-crosscheck-report.pdf