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Articles Published Processes
11/12/2026 3:43:55 AM | Browse: 0 | Download: 0
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Received |
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2026-06-12 10:50 |
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Peer-Review Started |
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2026-06-12 10:52 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-02 03:37 |
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Revised |
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2026-07-06 12:09 |
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Publication Fee Transferred |
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2026-07-08 09:10 |
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Second Decision by Editor |
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2026-08-31 03:15 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-31 08:44 |
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Articles in Press |
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2026-08-31 08:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-29 10:37 |
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Publish the Manuscript Online |
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2026-11-12 03:43 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Minireviews |
| Article Title |
Mechanisms, clinical translation, and future perspectives of liver-mediated immunoprotection in combined organ transplantation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zheng-Wei Zhao, Yu-Guo Chen and Guang-Yi Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guang-Yi Wang, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. guangyi@jlu.edu.cn |
| Key Words |
Liver transplantation; Intestinal transplantation; Multivisceral transplantation; Immune tolerance; Immunoprotection; Combined transplantation |
| Core Tip |
This review highlights the immunoprotective mechanisms of the liver in combined intestinal and multivisceral transplantation, including liver sinusoidal endothelial cell-mediated antigen presentation, regulatory T cell enrichment, clonal deletion, and donor-specific antibody clearance. Concurrent liver inclusion reduces rejection rates but increases risks of graft-vs-host disease and infection. Normothermic machine perfusion and regulatory T-cell therapy represent promising strategies for optimizing immunomodulation. |
| Publish Date |
2026-11-12 03:43 |
| Citation |
Zhao ZW, Chen YG, Wang GY. Mechanisms, clinical translation, and future perspectives of liver-mediated immunoprotection in combined organ transplantation. World J Gastrointest Surg 2026; 18(11): 124378
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| URL |
https://www.wjgnet.com/1948-9366/full/v18/i11/124378.htm |
| DOI |
https://doi.org/10.4240/wjgs.124378 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
